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CSK 抗体 (AA 330-450)

CSK 适用: 人, 小鼠 WB, IP, ICC 宿主: 小鼠 Monoclonal CSK-04 unconjugated
产品编号 ABIN94268
发货至: 中国
  • 抗原 See all CSK 抗体
    CSK (C-Src tyrosine Kinase (CSK))
    抗原表位
    • 19
    • 16
    • 12
    • 11
    • 8
    • 8
    • 7
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 330-450
    适用
    • 111
    • 56
    • 45
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 100
    • 10
    • 3
    小鼠
    克隆类型
    • 100
    • 12
    单克隆
    标记
    • 53
    • 9
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    This CSK antibody is un-conjugated
    应用范围
    • 101
    • 49
    • 26
    • 26
    • 16
    • 15
    • 13
    • 9
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    特异性
    The mouse monoclonal antibody CSK-04 reacts with Csk (C-terminal Src kinase), a 50 kDa intracellular non-receptor protein tyrosine kinase.
    交叉反应 (详细)
    Human, Mouse, Other not determined
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Bacterially expressed recombinant fragment of human Csk corresponding to aa 330-450.
    克隆位点
    CSK-04
    亚型
    IgG1
    Top Product
    Discover our top product CSK Primary Antibody
  • 应用备注
    Immunocytochemistry: Positive control: HeLa human cervix carcinoma cell line.
    Western blotting: The recommended dilution of the antibody CSK-04 is 1:250-1:300, weak non-specific band of cca 60 kDa is detected in human cell lines in lower antibody dilutions.
    Immunoprecipitation: The immunosorbent (CSK-04 antibody covalently bound to beads) immunoprecipitates Csk from cell lysates.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • 抗原
    CSK (C-Src tyrosine Kinase (CSK))
    别名
    Csk (CSK 产品)
    别名
    AW212630 antibody, C-terminal Src kinase antibody, c-src tyrosine kinase antibody, CSK, non-receptor tyrosine kinase antibody, CSK antibody, Csk antibody
    背景
    C-terminal Src kinase,C-terminal Src kinase (Csk) is a non-receptor protein tyrosine kinase which resembles Src-family kinases, but unlike them it lacks the conserved autophosphorylation site, the regulatory C-terminal tyrosine as well as myristylation and palmitylation. Csk negatively regulates Src-family kinases by phosphorylation of their C-terminal regulatory tyrosine. Disruption of the csk gene causes constitutive activation of Src-family kinases, and overexpression of Csk usually counteracts their signaling. The Csk-mediated regulation of those Src-family kinases, that are localized in lipid rafts, is enabled by a ubiquitously expressed transmembrane adaptor PAG (also known as Cbp, Csk-binding protein), which recruits Csk.
    基因ID
    1445
    UniProt
    P41240
    途径
    TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events
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