BMI1 抗体 (Middle Region) (PE)
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北京 101111
Quick Overview for BMI1 抗体 (Middle Region) (PE) (ABIN7972792)
抗原
See all BMI1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- Anti-Bmi1 Antibody PE Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins
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预测反应
- different from the related mouse sequence by four amino acids.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human Bmi1, different from the related mouse sequence by four amino acids.
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亚型
- IgG
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anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) antibody
BMI1 适用: 人, 小鼠 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB22858 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) antibodyBMI1 适用: 人 IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3E3 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 250-300) antibodyBMI1 适用: 人, 小鼠 WB, IHC, ICC, IP, FACS 宿主: 兔 Monoclonal BLR119H unconjugated Recombinant Antibody
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 142-326) antibodyBMI1 适用: 人, 小鼠 WB, IHC, IF 宿主: 小鼠 Monoclonal BMI1-2823 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 120-326) antibodyBMI1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 142-326) antibodyBMI1 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal BMI1-2689 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 1-326) antibodyBMI1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E10-1C5 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 142-326) antibodyBMI1 适用: 人 IHC 宿主: 小鼠 Monoclonal BMI1-2690 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 257-286), (C-Term) antibodyBMI1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB02926 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) antibodyKD Validated BMI1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB685 unconjugated Recombinant Antibody
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))
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别名
- BMI1
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背景
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Background: BMI1 (BMI1 polycomb ring finger oncogene), also known as RNF51, is a protein which in humans is encoded by the BMI1 gene. The Bmi1 gene is highly conserved in evolution as indicated by zoo blot hybridization with Bmi1 probes corresponding to the protein-encoding domain. By fluorescence in situ hybridization, the human BMI1 gene is assigned to chromosome 10p13. BMI1 has a key role in regulating the proliferative activity of normal stem and progenitor cells. Most importantly, they provided evidence that the proliferative potential of leukemic stem and progenitor cells lacking BMI1 is compromised because they eventually undergo proliferation arrest and show signs of differentiation and apoptosis, leading to transplant failure of the leukemia. Complementation studies showed that BMI1 completely rescues these proliferative defects. Deletion analysis showed that the RING finger and helix-turn-helix domains of BMI1 were required for life span extension and repression of the tumor suppressor p16 (INK4). BMI1 selectively extended the life span of these cultures. Confocal microscopy showed that BMI1 transiently colocalized with centromeres during interphase in HeLa cells.
Gene Full Name: COMMD3-BMI1 readthrough
Sequence Similarities: Contains 1 RING-type zinc finger.
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基因ID
- 648
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UniProt
- P35226
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途径
- Cell Division Cycle, Autophagy
抗原
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