ALOX5 抗体 (AA 120-483) (Biotin)
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Quick Overview for ALOX5 抗体 (AA 120-483) (Biotin) (ABIN7969862)
抗原
See all ALOX5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 120-483
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原理
- Anti-5 Lipoxygenase/ALOX5 Antibody Biotin Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- Human ALOX5 shares 94% amino acid (aa) sequence identity with both mouse,rat ALOX5.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human ALOX5 recombinant protein (Position: A120-R483). Human ALOX5 shares 94% amino acid (aa) sequence identity with both mouse and rat ALOX5.
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亚型
- IgG
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- ALOX5 (Arachidonate 5-Lipoxygenase (ALOX5))
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别名
- ALOX5
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背景
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Background: Arachidonate 5-lipoxygenase, also known as 5-LOX or 5-LO, is an enzyme that in humans is encoded by the ALOX5 gene. ALOX5 is a member of the lipoxygenase family of enzymes. It is mapped to 10q11.21. ALOX5 plays a dual role in the synthesis of leukotrienes from arachidonic acid. The position of ALOX5 within the nucleus of resting cells determines the capacity to generate LTB4 upon subsequent activation. It is involved in lung vascular tone regulation and in the development of chronic pulmonary hypertension in hypoxic rodent models. ALOX5 also transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases.
Gene Full Name: arachidonate 5-lipoxygenase
Sequence Similarities: Belongs to the lipoxygenase family.
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基因ID
- 240
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UniProt
- P09917
抗原
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