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Recombinant TARDBP 抗体

The 兔 单克隆 anti-TARDBP antibody is suitable to detect TARDBP in samples from 人, 小鼠 和 大鼠. It has been validated for WB.
产品编号 ABIN7938518
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for Recombinant TARDBP 抗体 (ABIN7938518)

抗原

See all TARDBP 抗体
TARDBP (TAR DNA Binding Protein (TARDBP))

抗体类型

Recombinant Antibody

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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单克隆

标记

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This TARDBP antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

11N20
  • 原理

    TARDBP antibody (rAb), 100 μl (Clone 11N20)

    纯化方法

    Protein A Chromatography

    免疫原

    This information is proprietary to Active Motif and/or its suppliers.

    亚型

    IgG
  • 应用备注

    WB: 1:5000-1:50000 dilution

    限制

    仅限研究用
  • 缓冲液

    Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

    储存条件

    -20 °C

    储存方法

    Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

    有效期

    24 months
  • 抗原

    TARDBP (TAR DNA Binding Protein (TARDBP))

    别名

    TARDBP

    背景

    Background_Plain: The TARDBP gene encodes the TDP-43 protein, initially found to repress HIV-1 transcription by binding TAR DNA. TDP-43 has since been shown to bind RNA as well as DNA, and have multiple functions in transcriptional repression, translational regulation and pre-mRNA splicing. For instance, it is reported to regulate alternate splicing of the CTFR gene. In 2006 Neumann et al. found that hyperphosphorylated, ubiquitinated and/or cleaved forms of TDP-43, collectively known as pathological TDP-43, play a major role in the disease mechanisms of ubiquitin-positive, tau- and alpha-synuclein-negative frontotemporal dementia (FTLD-U) and in amyotrophic lateral sclerosis (ALS).

    Aliases: TAR DNA-binding protein 43, ALS10, TDP-43

    分子量

    43 kDa

    途径

    Positive Regulation of Peptide Hormone Secretion
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