Recombinant TARDBP 抗体
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北京 101111
Quick Overview for Recombinant TARDBP 抗体 (ABIN7938518)
抗原
See all TARDBP 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- TARDBP antibody (rAb), 100 μl (Clone 11N20)
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纯化方法
- Protein A Chromatography
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免疫原
- This information is proprietary to Active Motif and/or its suppliers.
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亚型
- IgG
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应用备注
- WB: 1:5000-1:50000 dilution
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限制
- 仅限研究用
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缓冲液
- Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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- TARDBP (TAR DNA Binding Protein (TARDBP))
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别名
- TARDBP
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背景
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Background_Plain: The TARDBP gene encodes the TDP-43 protein, initially found to repress HIV-1 transcription by binding TAR DNA. TDP-43 has since been shown to bind RNA as well as DNA, and have multiple functions in transcriptional repression, translational regulation and pre-mRNA splicing. For instance, it is reported to regulate alternate splicing of the CTFR gene. In 2006 Neumann et al. found that hyperphosphorylated, ubiquitinated and/or cleaved forms of TDP-43, collectively known as pathological TDP-43, play a major role in the disease mechanisms of ubiquitin-positive, tau- and alpha-synuclein-negative frontotemporal dementia (FTLD-U) and in amyotrophic lateral sclerosis (ALS).
Aliases: TAR DNA-binding protein 43, ALS10, TDP-43
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分子量
- 43 kDa
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途径
- Positive Regulation of Peptide Hormone Secretion
抗原
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