EZH2 抗体 (AA 1-370)
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Quick Overview for EZH2 抗体 (AA 1-370) (ABIN7938125)
抗原
See all EZH2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-370
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原理
- EZH2 antibody (pAb)
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纯化方法
- Unpurified
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免疫原
- This EZH2 antibody was raised against a recombinant fusion protein corresponding to amino acids 1-370 of mouse EZH2.
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应用备注
- ChIP-Seq: 5 µL each CUT&RUN: 1 µL per 50 µL reaction This antibody has not been validated in WB, but a WB-validated antibody is available for this target: 39933. For EZH2, we also offer AbFlex EZH2 Recombinant Antibody (rAb). For details, see Catalog No. 91159.
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限制
- 仅限研究用
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缓冲液
- Rabbit serum containing 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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- EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
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别名
- EZH2
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背景
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Background_Plain: EZH2 - (Enhancer of Zeste homolog 2) is a human homolog of the Drosophila Polycomb-group protein Enhancer of Zeste protein. It contains a SET domain that catalyzes the methylation of histone H3 at lysine 27 (Histone H3 Lys27 monomethylated, dimethylated and trimethylated). Polycomb-group proteins repress gene expression by binding to chromatin and locally altering chromatin structure. EZH2, BMI-1 and Suz12 are present in the PRC2 and PRC3 protein complexes that function as mediators of epigenetic transcriptional silencing. EZH2 associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems. Deregulation of EZH2 is linked to a variety of cancers.
Aliases: WVS, ENX1, EZH1, KMT6, WVS2, ENX-1, EZH2b, KMT6A
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分子量
- 96 kDa
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NCBI登录号
- NP_031997
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途径
- Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
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