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RPS6KA3 抗体 (pThr573)

Name: RPS6KA3 抗体 (pThr573)
SKU: ABIN745223
Availability: OutOfStock

This anti-RPS6KA3 antibody is a 兔多克隆 antibody detecting RPS6KA3 in ELISA, IF (p), IF (cc), IHC (p), FACS 和 IHC (fro). Suitable for 人和小鼠.

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-Phospho-p90RSK (Thr573) Polyclonal Antibody, Unconjugated (ABIN745223) at 1:200 followed by conjugation to the secondary antibody and DAB staining. (RPS6KA3 抗体 (pThr573))

IHC

ELISA

2 images

产品编号 ABIN745223

发货至: 中国

Quick Overview for RPS6KA3 抗体 (pThr573) (ABIN745223)

抗原

See all RPS6KA3 抗体

RPS6KA3 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This RPS6KA3 antibody is un-conjugated

应用范围

ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product RPS6KA3 Primary Antibody

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pThr573

特异性

This antibody will cross react with Ribosomal protein S6 kinase alpha-6 when phosphorylated at Thr581

交叉反应

人, 小鼠

预测反应

Rat

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic phosphopeptide derived from human p90RSK around the phosphorylation site of Thr573

亚型

IgG
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) antibody
RPS6KA3 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 4E10 unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (AA 1-740) antibody
RPS6KA3 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (AA 2-95) antibody
RPS6KA3 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2G10 unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (Center) antibody
RPS6KA3 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (pTyr529) antibody
RPS6KA3 适用: 人, 小鼠 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (pSer227) antibody
RPS6KA3 适用: 人, 大鼠 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (AA 214-431) antibody
RPS6KA3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (pThr573) antibody
RPS6KA3 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (AA 2-95) antibody
RPS6KA3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) antibody
RPS6KA3 适用: 人, 小鼠, 猴 WB, IP 宿主: 小鼠 Monoclonal 6B9-D6-F8 unconjugated

应用备注

ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
抗原

RPS6KA3 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3))

别名

p90RSK

背景

Synonyms: Ribosomal protein S6 kinase alpha-1, S6K-alpha-1, 90 kDa ribosomal protein S6 kinase 1, p90-RSK 1, p90RSK1, p90S6K, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, Ribosomal S6 kinase 1, RSK-1, RPS6KA1, MAPKAPK1A, RSK1
Background: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4).

基因ID

6195

UniProt

Q15418

途径

MAPK Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades