Ephrin B2 抗体 (Extracellular, N-Term)
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Quick Overview for Ephrin B2 抗体 (Extracellular, N-Term) (ABIN7884946)
抗原
See all Ephrin B2 (EFNB2) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 181-193, Extracellular, N-Term
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原理
- A Rabbit Polyclonal antibody to Ephrin-B2 (extracellular)
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预测反应
- Mouse,rat - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RRPELEAGTNGRS, corresponding to amino acid residues 181 - 193 of human Ephrin-B2
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亚型
- IgG
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anti-Ephrin B2 (EFNB2) (C-Term) antibody
EFNB2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ephrin B2 (EFNB2) (AA 28-229) antibodyEFNB2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ephrin B2 (EFNB2) antibodyKD Validated EFNB2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2345 unconjugated Recombinant Antibody
anti-Ephrin B2 (EFNB2) (AA 157-186) antibodyEFNB2 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB31411 unconjugated
anti-Ephrin B2 (EFNB2) antibodyEFNB2 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ephrin B2 (EFNB2) antibodyEFNB2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Ephrin B2 (EFNB2) (AA 28-127) antibodyEFNB2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ephrin B2 (EFNB2) (pTyr330) antibodyEFNB2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ephrin B2 (EFNB2) antibodyEFNB2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ephrin B2 (EFNB2) (AA 28-229) antibodyEFNB2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Ephrin B2 (EFNB2)
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别名
- EFNB2
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背景
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Synonyms: EFNB2, EPH-Related Receptor Tyrosine Kinase Ligand 5, LERK5, HTK ligand, HTKL
Description: Ephrin-B2 is a ligand for RTK Eph receptors, mediating cell adhesion and repulsion-segregation, thus influencing cell migration and tissue morphogenesis and angiogenesis. Ephrin-B2 is highly expressed in the nervous system during development and required for neuronal survival. Also expressed in the brain and lung endothelial cells (EC) for angiogenesis. It is overexpressed in various cancers.The erythropoietin-producing hepatocellular (Eph) receptors represent the largest known family of receptor tyrosine kinases and are activated by interactions with cell-surface ligands, termed ephrins. Eph receptors have been classified into two subfamilies, EphA and EphB, according to their preference for either glycosylphosphatidylinositol (GPI)-anchored ephrin-A ligands (ephrin-A1 to -A5) or transmembrane ephrin-B ligands (ephrin-B1 to -B3). All ephrin ligands share a conserved core sequence of approximately 125 amino acids, including 4 invariant cysteine residues, probably corresponding to a receptor binding domain 1.Ephrin-B2 is a cell surface transmembrane ligand 2. Ephrin-B2 binds Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Forward and reverse signaling through Eph receptors is a unique characteristic to this RTK since ephrins are physically linked to the plasma membrane 3. For example, in angiogenesis EphB4-mediated forward signaling controls cellular repulsion and segregation from ephrin-B2-expressing cells, resulting in distinction between EphB4-expressing veins and ephrin-B2-expressing arteries 4.Eph receptors and ephrins are highly expressed in the brain and in the developing nervous system, where they are involved in fundamental developmental processes of the nervous system, including axon guidance, axon fasciculation, neural crest cell migration, acquisition of brain subregional identity, and neuronal cell survival. They are also implicated in Alzheimer's disease, and other neurodegenerative disorders 5.Nipah virus (NiV) infection has both respiratory and encephalitic components and several cell types are targets of NiV, dictated by the expression of the ephrin-B2/3 ligand on the cell's outer membrane, which interact with the NiV surface proteins. ephrin-B2 and ephrin-B3 on cells, are the only identified receptors for NiV and Hendra virus (HeV) from the family Paramyxoviridae. Vascular endothelial cells (ECs) are the major targets of infection by NiV and HeV 6 .In cancer cells, Eph receptors and ephrins are overexpressed. Eph receptor bidirectional signaling with both tumor-promoting and tumor-suppressing activities has been observed in different cancer types and their microenvironments. EphB2 is aberrantly expressed in many cancer types, such as colorectal cancer, gastric cancer and hepatocellular carcinoma, driving tumorigenesis and tumor progression 7.
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基因ID
- 1948
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UniProt
- P52799
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途径
- RTK signaling, Regulation of Muscle Cell Differentiation
抗原
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