Contactin 1 抗体 (Extracellular, N-Term)
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Quick Overview for Contactin 1 抗体 (Extracellular, N-Term) (ABIN7884895)
抗原
See all Contactin 1 (CNTN1) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 947-961, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Contactin-1 (extracellular)
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预测反应
- Mouse - identical, human - 14,15 amino acid residues identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RPDGQHDGKLFSTHK, corresponding to amino acid residues 947 - 961 of rat Contactin-1
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亚型
- IgG
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anti-Contactin 1 (CNTN1) (AA 250-350) antibody
CNTN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) antibodyCNTN1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) antibodyCNTN1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) (AA 585-870) antibodyVerified CNTN1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) (Internal Region) antibodyVerified CNTN1 适用: 人, 大鼠, 小鼠, Pig WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) (AA 947-961), (Extracellular), (N-Term) antibodyCNTN1 适用: 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) (AA 686-866) antibodyCNTN1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) (AA 81-130) antibodyCNTN1 适用: 人, 大鼠, Pig, 豚鼠, 马, Cow, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) (AA 301-350) antibodyCNTN1 适用: 人, 大鼠, 小鼠, Pig, 豚鼠, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) (N-Term) antibodyCNTN1 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200-1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235161)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Contactin 1 (CNTN1)
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别名
- Neural cell surface protein F3
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背景
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Synonyms: Neural cell surface protein F3, Glycoprotein GP135, CNTN1
Description: Contactin-1 (CNTN1), also known as F3/Contactin a cell adhesion molecule, is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein involved in neuronal development, synaptic maintenance and organization of neuronal networks. CNTNs are a subpopulation of molecules belonging to the immunoglobulin (Ig) superfamily, which includes six members: CNTN1, TAG-1/CNTN2, BIG-1/CNTN3, BIG-2/CNTN4, NB-2/CNTN5 and NB-3/CNTN61,2.In mammals, contactin-1 is mostly localized in the peripheral and central neural system. It is highly expressed at the axonal level and mediates various functions in both glial and neuronal cells, it is involved in neuronal and glial development and differentiation, myelination, synaptogenesis and synaptic function1.Contactin-1 expression profile differs in various brain regions and, within each area, it changes depending upon the cell type. For example, in the cerebellar cortex contactin-1 is predominant in granule cells in earlier developmental stages, whereas its activation is delayed in Purkinje neurons. In the hippocampus, it is detected on pyramidal neurons of CA1-CA3 fields and in granule layers of Dentate Gyrus (DG) where its expression persists in postnatally developed neurons. Hippocampal contactin-1 is highly expressed in the developing hippocampus, it progressively increases during postnatal life, but it declines during aging, paralleling cognitive impairment. This suggests that contactin-1 might play a role in memory processes, in line with studies indicating its involvement in neurotransmitter release and some forms of plasticity1.The role of contactin-1 in neurotransmitter release has been linked with its capability to regulate synaptic vesicle exocytosis. Contactin-1 overexpression had been shown to induce an increase of cAMP-Responsive Element Binding (CREB) phosphorylation, enhanced hippocampal-dependent LTP and memory especially in 12-months-old mice, where neurogenesis is particularly evident. Also, contactin-1 overexpression counteracts apoptosis, and induces an increase of the antiapoptotic- and neuroplasticity-pathway BDNF/CREB/Bcl-21,3.Contactin-1 plays an important role in cancer progression. The expression of contactin-1 is upregulated in primary lesions, and its expression level correlates with tumor metastasis in cancer patients. Studies have demonstrated that contactin-1 also plays a key role in diseases not related to the nervous system, and its most notable function is its participation in cancer progression, in cancers such as esophageal squamous cell carcinoma (ESCC), GC, lung adenocarcinoma, oral squamous cell carcinoma (OSCC), hepatocellular carcinoma and prostate cancer2,3.
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基因ID
- 117258
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UniProt
- Q63198
抗原
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