MERTK 抗体 (Extracellular, N-Term)
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Quick Overview for MERTK 抗体 (Extracellular, N-Term) (ABIN7884799)
抗原
See all MERTK 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 402-416, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to MERTK Receptor
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预测反应
- Rat - identical, human - 13,15 amino acid residues identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KPPIKRQDGELVGYR, corresponding to amino acid residues 402 - 416 of mouse MERTK
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亚型
- IgG
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anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 587-858) antibody
MERTK 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 501-600) antibodyMERTK 适用: 小鼠 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-489) antibodyMERTK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) antibodyMERTK 适用: 人 WB, IHC, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 402-416), (Extracellular), (N-Term) antibodyMERTK 适用: 小鼠 WB, IHC, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 55-148) antibodyMERTK 适用: 人 IHC 宿主: 小鼠 Monoclonal MERTK-3015 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) antibodyMERTK 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB17701 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-120) antibodyMERTK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D2 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 840-999) antibodyMERTK 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) antibodyKD Validated MERTK 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2070 unconjugated Recombinant Antibody
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应用备注
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WB: 1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7234888)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
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别名
- Receptor tyrosine kinase MerTK
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背景
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Synonyms: Receptor tyrosine kinase MerTK, C-Mer Proto-Oncogene Tyrosine Kinase, Mer, Proto-Oncogene C-Mer
Description: Myeloid-epithelial-reproductive tyrosine kinase, MERTK, is a receptor tyrosine kinase of the TAM (Tyro3, Axl and MERTK) family, expressed in numerous cancers1.The extracellular N-terminal domain contains two immunoglobulin-like and two fibronectin 3 domains, followed by a hydrophobic single pass transmembrane domain, and a cytoplasmic C-terminal tail containing a tyrosine kinase domain1,2.Auto-phosphorylation induced by ligand binding influences a range of downstream signaling pathways and cellular functions2. The physiological roles of MERTK include regulation of tissue homeostasis and repair, innate immune control, and platelet aggregation. However, aberrant expression of this protein promotes neoplasia, cell cycle progression, proliferation and tumor growth, resistance to apoptosis, and promotion of tumor metastases.MERTK is involved in the activation of several canonic oncogenic signaling pathways in various types of cancers including: leukemia, non-small cell lung cancer, glioblastoma, melanoma, prostate cancer, breast cancer, colon cancer and gastric cancer1,3,4.Due to its pivotal role in cancer development and metastasis, multiple therapeutic approaches are currently in development to inhibit MERTK, including ligand "traps" and small-molecule tyrosine kinase inhibitors4.
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基因ID
- 17289
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UniProt
- Q60805
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途径
- RTK signaling
抗原
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