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MERTK 抗体 (AA 55-148)

MERTK 适用: 人 IHC, IHC (f) 宿主: 小鼠 Monoclonal MERTK-3015 unconjugated
产品编号 ABIN6939061
发货至: 中国
  • 抗原 See all MERTK 抗体
    MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
    抗原表位
    • 13
    • 11
    • 8
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 55-148
    适用
    • 75
    • 38
    • 29
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 70
    • 9
    • 2
    • 1
    小鼠
    克隆类型
    • 61
    • 21
    单克隆
    标记
    • 48
    • 9
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This MERTK antibody is un-conjugated
    应用范围
    • 54
    • 45
    • 32
    • 14
    • 12
    • 11
    • 10
    • 9
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    特异性
    MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.
    交叉反应 (详细)
    Human,
    纯化方法
    200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
    免疫原
    Recombinant human MERTK protein fragment (around aa 55-148) (exact sequence is proprietary)
    克隆位点
    MERTK-3015
    亚型
    IgG2a
    Top Product
    Discover our top product MERTK Primary Antibody
  • 应用备注

    Positive Control: Human colon tissue (IHC).

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    限制
    仅限研究用
  • 浓度
    200 μg/mL
    缓冲液
    Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-80 °C
    储存方法
    Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
    有效期
    24 months
  • 抗原
    MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
    别名
    MERTK (MERTK 产品)
    别名
    MER antibody, RP38 antibody, c-mer antibody, Eyk antibody, Mer antibody, Nyk antibody, nmf12 antibody, rdy antibody, C-EYK antibody, MERTK antibody, DKFZp469D2215 antibody, si:ch1073-268l12.2 antibody, MER proto-oncogene, tyrosine kinase antibody, c-mer proto-oncogene tyrosine kinase antibody, c-mer proto-oncogene tyrosine kinase a antibody, MERTK antibody, Mertk antibody, mertka antibody
    背景
    CEyk, MER receptor tyrosine kinase, MERK, MERPEN, nmf12, Nyk, Proto-oncogene c-Mer, RP38, STK kinase,MerTK (Innate Immune Checkpoint)
    Cellular localisation: Cell surface.
    分子量
    110kDa
    基因ID
    10461, 306178
    UniProt
    Q12866
    途径
    RTK signaling
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