XRCC6 抗体
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北京 101111
Quick Overview for XRCC6 抗体 (ABIN7882709)
抗原
See all XRCC6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Ku70/XRCC6 Antibody
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序列
- AIVEKLRFTY RSDSFENPVL QQHFRNLEAL ALD
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纯化方法
- Antigen affinity purified
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免疫原
- Amino acids AIVEKLRFTYRSDSFENPVLQQHFRNLEALALD were used as the immunogen for the Ku70/XRCC6 antibody.
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亚型
- IgG1
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anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) (AA 1-609) antibody
XRCC6 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4C2-1A6 unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) (C-Term) antibodyXRCC6 适用: 人 WB, IF, IHC (p), ICC, IP, PLA 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) (AA 397-603) antibodyXRCC6 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) (AA 319-538) antibodyXRCC6 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) (AA 408-609) antibodyXRCC6 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) (AA 6-214) antibodyXRCC6 适用: 人 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 2F7F5 unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) antibodyXRCC6 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) (acLys542) antibodyXRCC6 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) (AA 521-548), (C-Term) antibodyXRCC6 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB20806 unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) (C-Term) antibodyXRCC6 适用: 人 WB, IHC, IF, FACS, ICC 宿主: 小鼠 Monoclonal 3D7 unconjugated
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应用备注
- Optimal dilution of the Ku70/XRCC6 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Ku70/XRCC6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))
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别名
- Ku70/XRCC6
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背景
- XRCC6 (X-Ray Repair, Complementing Defective, In Chinese Hamster, 6), also called Ku70, G22P1 or TLAA, is a protein that in humans, is encoded by the XRCC6 gene. In addition, the XRCC6 gene encodes subunit p70 of the p70/p80 autoantigen which consists of 2 proteins of molecular mass of approximately 70,000 and 80,000 daltons that dimerize to form a 10 S DNA-binding complex. The XRCC6 gene is mapped to 22q13.2. XRCC6 and Mre11 are differentially expressed during meiosis. XRCC6 interacts with Baxa, a mediator of mitochondrial-dependent apoptosis. Disruption of both FANCC and XRCC6 suppressed sensitivity to crosslinking agents, diminished chromosome breaks, and reversed defective homologous recombination. Ku70 binds directly to free DNA ends, committing them to NHEJ repair. In early meiotic prophase, however, when meiotic recombination is most probably initiated, Mre11 was abundant, whereas XRCC6 was not detectable.
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UniProt
- P12956
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途径
- DNA Damage Repair
抗原
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