p63 抗体
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北京 101111
Quick Overview for p63 抗体 (ABIN7882600)
抗原
See all p63 (TP63) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- deltaNp63 Antibody / p40
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序列
- ENNAQTQFSE PQY
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纯化方法
- Protein A affinity chromatography
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免疫原
- Amino acids ENNAQTQFSEPQY were used as the immunogen for the deltaNp63 antibody.
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亚型
- IgG
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anti-Tumor Protein P63 (TP63) antibody
KO Validated TP63 适用: 人 WB, ICC, IF, IP, IHC (p), IHC (fro), PLA 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P63 (TP63) (AA 421-680) antibodyTP63 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P63 (TP63) (AA 5-17) antibodyTP63 适用: 人, 小鼠, 大鼠, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P63 (TP63) antibodyTP63 适用: 人 IHC, FACS 宿主: 小鼠 Monoclonal TP63-2428 unconjugated
anti-Tumor Protein P63 (TP63) (AA 3-106) antibodyTP63 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal TP63-1786 unconjugated
anti-Tumor Protein P63 (TP63) antibodyTP63 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Tumor Protein P63 (TP63) (AA 664-680), (C-Term) antibodyTP63 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P63 (TP63) (C-Term) antibodyTP63 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P63 (TP63) antibodyTP63 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P63 (TP63) antibodyTP63 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal TP63-11 unconjugated
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应用备注
- Optimal dilution of the deltaNp63 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the deltaNp63 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- p63 (TP63) (Tumor Protein P63 (TP63))
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别名
- deltaNp63
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背景
- P63 consists of two major isoforms-TAp63 and delta-Np63. These isoforms differ in the structure of the N-terminal domains. The TAp63 isoform (identified by anti-p63 antibody) contains a transactivation-competent TA domain with homology to p53, which regulates the expression of the growth-inhibitory genes. In contrast, DNp63 isoform (identified by anti-p40 antibody) contains an alternative transcriptionally-inactive delta-N domain, which antagonizes the activity of TAp63 and p53. The p40 (clone ZR8) antibody recognizes exclusively delta-Np63 but not TAp63. p40 is a squamous cell carcinoma specific antibody. It reacts with the vast majority of cases of squamous cell carcinomas of various origins, but not with adenocarcinomas. It is particularly useful in differentiating lung squamous cell carcinoma from lung poorly differentiated adenocarcinoma. p40 antibody can also be used as an alternative basal cell/myoepithelial cell marker, which has similar sensitivity and specificity as that of p63 antibody. Therefore, p40 antibody may also be used as an alternative immunohistochemical marker for determining prostate adenocarcinoma vs. benign prostate glands and for determining breast intraductal carcinoma vs. invasive breast ductal carcinoma.
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UniProt
- Q9H3D4
抗原
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