Recombinant PABPN1 抗体
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北京 101111
Quick Overview for Recombinant PABPN1 抗体 (ABIN7881992)
抗原
See all PABPN1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PABPN1 Antibody / Polyadenylate-binding protein 2
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to human PABPN1 was used as the immunogen for the PABPN1 antibody.
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亚型
- IgG
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anti-Poly A Binding Protein Nuclear 1 (PABPN1) antibody
PABPN1 适用: 人, 小鼠, 大鼠 IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Poly A Binding Protein Nuclear 1 (PABPN1) antibodyPABPN1 适用: 人 WB, IF, IHC, FACS, ELISA 宿主: 兔 Monoclonal 6C3 unconjugated Recombinant Antibody
anti-Poly A Binding Protein Nuclear 1 (PABPN1) (N-Term) antibodyPABPN1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔 WB, ICC 宿主: 兔 Polyclonal unconjugated
anti-Poly A Binding Protein Nuclear 1 (PABPN1) antibodyPABPN1 适用: 人 WB, IF, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Poly A Binding Protein Nuclear 1 (PABPN1) (N-Term) antibodyPABPN1 适用: 人, 大鼠, 犬, Cow, 豚鼠, 兔, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Poly A Binding Protein Nuclear 1 (PABPN1) (AA 1-100) antibodyPABPN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poly A Binding Protein Nuclear 1 (PABPN1) (AA 100-150) antibodyPABPN1 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Poly A Binding Protein Nuclear 1 (PABPN1) (AA 1-50) antibodyPABPN1 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Poly A Binding Protein Nuclear 1 (PABPN1) (C-Term) antibodyPABPN1 适用: 人, 小鼠 WB, IF, IHC, ICC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Poly A Binding Protein Nuclear 1 (PABPN1) (AA 270-298), (C-Term) antibodyPABPN1 适用: 人 WB 宿主: 兔 Polyclonal RB36573 unconjugated
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应用备注
- Optimal dilution of the PABPN1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the PABPN1 antibody at -20oC.
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- PABPN1 (Poly A Binding Protein Nuclear 1 (PABPN1))
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别名
- PABPN1
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背景
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PABPN1 antibody is a key reagent for studying RNA processing, gene expression, and human disease. The encoded protein, polyadenylate-binding protein nuclear 1 (also known historically as polyadenylate-binding protein 2), is a nuclear RNA-binding protein that regulates the length of the poly(A) tail added to pre-mRNA transcripts. By binding to nascent polyadenylated RNA, PABPN1 stimulates poly(A) polymerase activity and ensures proper tail length, which is critical for mRNA stability, export, and translation efficiency.
PABPN1 functions primarily in the nucleus, where it coordinates with other RNA-binding proteins and processing factors to promote accurate maturation of mRNA. Beyond its role in polyadenylation, PABPN1 has been implicated in alternative polyadenylation site choice, thereby influencing transcript diversity and gene regulation. Through these activities, PABPN1 contributes to global control of gene expression and adaptation to cellular conditions.
Mutations in PABPN1 cause oculopharyngeal muscular dystrophy (OPMD), a late-onset genetic disorder characterized by progressive weakening of the eyelid, pharyngeal, and proximal limb muscles. The disease is associated with expansion mutations in the polyalanine tract of PABPN1, leading to nuclear aggregation of the protein and impaired RNA processing. This connection highlights the essential role of PABPN1 in muscle cell biology and its broader significance in human health.
In addition to OPMD, altered PABPN1 function has been linked to cancer and neurodegeneration, where dysregulated RNA processing contributes to disease progression. Studies suggest that changes in PABPN1 activity may affect transcriptome profiles and cellular stress responses, making it a protein of interest in both basic and translational research. Its role in regulating mRNA maturation also positions it as a critical node in pathways that integrate transcription and translation.
The PABPN1 antibody is commonly applied in western blotting, immunohistochemistry, immunofluorescence, and flow cytometry to evaluate protein expression, nuclear localization, and disease-related alterations. These applications support research into RNA metabolism, muscular dystrophy, and transcriptome regulation. For scientists investigating RNA processing, muscle pathology, or gene expression control, the PABPN1 antibody provides a reliable detection reagent. NSJ Bioreagents supplies validated antibodies that ensure reproducibility and accuracy in advanced molecular studies.UCHL3 is widely expressed across tissues and has been linked to key biological processes including DNA repair, cell cycle regulation, and stress responses. Dysregulation of UCHL3 has been associated with cancer, neurodegeneration, and impaired protein degradation pathways. Employing a UCHL3 antibody provides insights into its diverse cellular functions and disease associations.
NSJ Bioreagents offers a high-quality UCHL3 antibody validated for applications such as western blot, immunohistochemistry, and immunoprecipitation. Using a UCHL3 antibody ensures sensitive and reproducible detection in studies of ubiquitin biology, proteostasis, and disease mechanisms.
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UniProt
- Q86U42
抗原
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