Recombinant PDGFB 抗体
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北京 101111
Quick Overview for Recombinant PDGFB 抗体 (ABIN7881962)
抗原
See all PDGFB 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PDGFB Antibody / Platelet derived growth factor subunit B
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human PDGF B was used as the immunogen for the PDGFB antibody.
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亚型
- IgG
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anti-Platelet Derived Growth Factor Subunit B (PDGFB) (AA 20-241) antibody
PDGFB 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Subunit B (PDGFB) (AA 30-110) antibodyPDGFB 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Subunit B (PDGFB) (AA 155-210) antibodyPDGFB 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Subunit B (PDGFB) (AA 84-199) antibodyPDGFB 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Subunit B (PDGFB) (AA 1-241) antibodyPDGFB 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Subunit B (PDGFB) (C-Term) antibodyVerified PDGFB 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Subunit B (PDGFB) (N-Term) antibodyPDGFB 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Subunit B (PDGFB) (AA 212-241), (C-Term) antibodyPDGFB 适用: 人 WB, IF 宿主: 兔 Polyclonal RB2203 unconjugated
anti-Platelet Derived Growth Factor Subunit B (PDGFB) (AA 82-190) antibodyPDGFB 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Subunit B (PDGFB) (N-Term) antibodyPDGFB 适用: 人, 大鼠, 小鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PDGFB antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the PDGFB antibody at -20oC.
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- PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))
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别名
- PDGFB
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背景
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PDGFB antibody detects Platelet derived growth factor subunit B, encoded by the PDGFB gene. Platelet derived growth factor subunit B is a growth factor that dimerizes to form homodimers or heterodimers with the PDGFA subunit, creating PDGF-BB or PDGF-AB ligands. These ligands bind to platelet derived growth factor receptors, initiating signaling cascades that control proliferation, survival, and migration of mesenchymal cells. PDGFB antibody provides researchers with a specific reagent to study angiogenesis, wound healing, and cancer biology.
Platelet derived growth factor subunit B is secreted as part of a larger precursor protein that undergoes proteolytic processing to yield the mature growth factor. Research using PDGFB antibody has demonstrated that PDGF-BB is a potent mitogen for fibroblasts, vascular smooth muscle cells, and pericytes. Its signaling regulates blood vessel development and maintenance, making it essential for embryonic angiogenesis and adult vascular remodeling. Knockout models lacking PDGFB develop severe vascular abnormalities, underscoring its importance in development.
Aberrant expression of Platelet derived growth factor subunit B has been linked to a wide range of diseases. Studies with PDGFB antibody have shown that overexpression promotes tumor growth and angiogenesis by stimulating stromal proliferation and vascular recruitment. In fibrotic disease, excess PDGFB drives fibroblast activation and extracellular matrix deposition. Conversely, deficiency in PDGFB signaling results in defective pericyte recruitment and fragile vasculature. These findings demonstrate its critical role in tissue integrity and pathology.
PDGFB also contributes to neurobiology. Research using PDGFB antibody has revealed that the protein supports neural progenitor proliferation and protects neurons from injury through trophic signaling. Dysregulation has been associated with neurodegenerative conditions and gliomas. Because of its diverse functions across tissues, Platelet derived growth factor subunit B remains an important therapeutic target.
PDGFB antibody is widely applied in western blotting, immunohistochemistry, and ELISA. Western blotting detects mature and precursor forms, immunohistochemistry highlights expression in vasculature and tumors, and ELISA quantifies secreted PDGFB in biological fluids. These applications make PDGFB antibody valuable in both basic and translational research.
By supplying validated PDGFB antibody reagents, NSJ Bioreagents supports studies into growth factor biology, angiogenesis, and cancer. Detection of Platelet derived growth factor subunit B allows researchers to examine how growth factor signaling regulates development, disease, and repair. -
UniProt
- P01127
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
抗原
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