Recombinant PPARG 抗体
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Quick Overview for Recombinant PPARG 抗体 (ABIN7881920)
抗原
See all PPARG 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PPAR gamma Antibody / PPARG
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human PPAR gamma was used as the immunogen for the PPAR gamma antibody.
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亚型
- IgG
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anti-Peroxisome Proliferator-Activated Receptor gamma (PPARG) (AA 315-420) antibody
PPARG 适用: 人, 小鼠, 大鼠, 山羊 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor gamma (PPARG) (AA 101-200) antibodyPPARG 适用: 人, 小鼠, 大鼠, Cow, 绵羊 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor gamma (PPARG) (pSer112) antibodyPPARG 适用: 人, 小鼠, 大鼠, 犬 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor gamma (PPARG) (AA 149-273) antibodyPPARG 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor gamma (PPARG) (pSer112) antibodyPPARG 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor gamma (PPARG) (pSer273) antibodyPPARG 适用: 人, 小鼠, 大鼠, 绵羊, 豚鼠 WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor gamma (PPARG) antibodyPPARG 适用: 人 WB, IHC, ELISA, IF 宿主: 小鼠 Monoclonal 8D1H8F4 unconjugated
anti-Peroxisome Proliferator-Activated Receptor gamma (PPARG) (AA 1-30), (N-Term) antibodyPPARG 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB22139 unconjugated
anti-Peroxisome Proliferator-Activated Receptor gamma (PPARG) (AA 311-493) antibodyPPARG 适用: 大鼠 WB, IHC 宿主: 小鼠 Monoclonal C5 unconjugated
anti-Peroxisome Proliferator-Activated Receptor gamma (PPARG) (AA 349-488) antibodyPPARG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PPAR gamma antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the PPAR gamma antibody at -20oC.
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- PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))
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别名
- PPAR gamma
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背景
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PPAR gamma antibody targets peroxisome proliferator activated receptor gamma, a nuclear receptor encoded by the PPARG gene. PPAR gamma functions as a ligand activated transcription factor and plays essential roles in adipocyte differentiation, glucose metabolism, and lipid storage. It binds to specific DNA sequences as a heterodimer with RXR, regulating genes involved in insulin sensitivity, fatty acid uptake, and inflammatory responses.
PPAR gamma exists in at least two isoforms, PPAR gamma 1 and PPAR gamma 2, which differ in tissue distribution and regulatory control. PPAR gamma 1 is broadly expressed, while PPAR gamma 2 is more adipocyte specific. Both isoforms are activated by endogenous ligands such as prostaglandin derivatives and polyunsaturated fatty acids, as well as synthetic ligands like thiazolidinediones. These synthetic agonists have been widely used as antidiabetic medications, making PPAR gamma antibody an important reagent in metabolic disease research.
The receptor is also implicated in cancer biology. PPAR gamma can regulate cell cycle arrest, apoptosis, and differentiation. Studies using PPAR gamma antibody have shown altered expression in breast, colon, and prostate cancers. Inflammation research has further demonstrated that PPAR gamma modulates immune responses by suppressing pro inflammatory cytokine production in macrophages and T cells.
Detection of PPAR gamma with PPAR gamma antibody is routinely carried out in western blotting, immunohistochemistry, and chromatin immunoprecipitation. Western blotting reveals isoform specific expression, while immunohistochemistry highlights nuclear localization. Chromatin immunoprecipitation assays combined with next generation sequencing have uncovered PPAR gamma binding sites across the genome, providing insights into transcriptional networks controlling energy homeostasis.
PPAR gamma remains a therapeutic target for type 2 diabetes, obesity, and cardiovascular disease. Researchers rely on PPAR gamma antibody to study receptor expression, ligand responsiveness, and downstream signaling changes under physiological and pathological conditions. Availability of validated antibodies such as those from NSJ Bioreagents supports reproducible discovery in metabolic research and drug development. -
UniProt
- P37231
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途径
- MAPK Pathway, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
抗原
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