Recombinant LAG3 抗体
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北京 101111
Quick Overview for Recombinant LAG3 抗体 (ABIN7881490)
抗原
See all LAG3 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- LAG-3 Antibody / Lymphocyte activation gene 3 protein / CD223
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human CD223 was used as the immunogen for the LAG-3 antibody.
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亚型
- IgG
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anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 500-525) antibody
LAG3 适用: 人 WB, IHC, ICC, FACS, IP, IF (p), mIF 宿主: 兔 Monoclonal BLR027F unconjugated Recombinant Antibody
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 103-132) antibodyLAG3 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21775 unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) antibodyLAG3 适用: 人 WB, IHC, ICC, FACS, IP, IF (p) 宿主: 兔 Monoclonal BLR028F unconjugated Recombinant Antibody
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 66-199) antibodyLAG3 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4H6A3 unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 103-132) antibodyLAG3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 29-450) antibodyLAG3 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 8B12E10 unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 1-360) antibodyLAG3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 250-300) antibodyLAG3 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Monoclonal BLR261L unconjugated Recombinant Antibody
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 201-300) antibodyLAG3 适用: 人, 小鼠 WB, ELISA, ICC, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) antibodyLAG3 适用: 小鼠 FACS, IP, BP 宿主: 兔 Chimeric C9B7W unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the LAG-3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the LAG-3 antibody at -20oC.
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- LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
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别名
- LAG-3
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背景
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LAG-3 antibody detects lymphocyte activation gene 3 protein, an immune checkpoint receptor encoded by the LAG3 gene. LAG-3 is expressed on activated T cells, natural killer cells, and plasmacytoid dendritic cells. It binds MHC class II molecules and negatively regulates T cell proliferation and activation. This checkpoint function maintains immune tolerance and prevents autoimmunity, but also contributes to immune evasion in cancer.
LAG-3 antibody is widely applied in immunology, oncology, and translational research. In cancer, LAG-3 expression marks exhausted T cells within the tumor microenvironment. In chronic infection, sustained LAG-3 expression dampens antiviral responses. By detecting LAG-3, researchers can evaluate immune exhaustion, tolerance mechanisms, and therapeutic checkpoint blockade strategies.
Flow cytometry with LAG-3 antibody identifies exhausted or regulatory T cell subsets. Immunohistochemistry maps LAG-3 expression in tumors and inflamed tissues, while immunofluorescence highlights surface distribution on lymphocytes. Western blotting confirms expression in activated immune cell lysates. These methods enable detailed characterization of immune checkpoint biology.
LAG-3 has therapeutic relevance as a target for immune checkpoint inhibitors. Antibodies blocking LAG-3 restore T cell function and enhance antitumor immunity. Clinical trials are evaluating LAG-3 blockade alone and in combination with PD-1 inhibitors. By applying LAG-3 antibody, scientists can monitor expression as a biomarker for patient selection and therapeutic response.
LAG-3 is also involved in autoimmune disease and transplantation. It modulates T regulatory cell function and dendritic cell activation, influencing tolerance and graft survival. Studying LAG-3 with antibody based methods provides insights into balancing immunity and tolerance in clinical settings.
LAG-3 antibody from NSJ Bioreagents provides strong specificity for detecting this checkpoint receptor. Its performance across multiple assays supports both basic and translational research in immunology and cancer therapy. -
UniProt
- P18627
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
抗原
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