Recombinant IFT88 抗体
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北京 101111
Quick Overview for Recombinant IFT88 抗体 (ABIN7881323)
抗原
See all IFT88 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- IFT88 Antibody / Intraflagellar transport protein 88
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human IFT88 was used as the immunogen for the IFT88 antibody.
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亚型
- IgG
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anti-Intraflagellar Transport 88 Homolog (IFT88) (C-Term) antibody
Verified IFT88 适用: 人, 小鼠 WB, IF, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Intraflagellar Transport 88 Homolog (IFT88) (AA 791-820), (C-Term) antibodyIFT88 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB24875 unconjugated
anti-Intraflagellar Transport 88 Homolog (IFT88) (AA 791-820) antibodyIFT88 适用: 人, 小鼠 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Intraflagellar Transport 88 Homolog (IFT88) antibodyKD Validated IFT88 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB4015 unconjugated Recombinant Antibody
anti-Intraflagellar Transport 88 Homolog (IFT88) (C-Term) antibodyIFT88 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Intraflagellar Transport 88 Homolog (IFT88) (AA 798-827), (C-Term) antibodyIFT88 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Intraflagellar Transport 88 Homolog (IFT88) antibodyIFT88 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Intraflagellar Transport 88 Homolog (IFT88) (AA 724-833) antibodyIFT88 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Intraflagellar Transport 88 Homolog (IFT88) (N-Term) antibodyIFT88 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 斑马鱼, 猴, Bat, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Intraflagellar Transport 88 Homolog (IFT88) (AA 721-770) antibodyIFT88 适用: 人, 小鼠, 大鼠, 豚鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the IFT88 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the IFT88 antibody at -20oC.
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- IFT88 (Intraflagellar Transport 88 Homolog (IFT88))
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别名
- IFT88
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背景
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IFT88 antibody recognizes Intraflagellar transport protein 88, encoded by the IFT88 gene. This protein is a core component of the intraflagellar transport complex B, which is essential for the formation and maintenance of cilia and flagella. Intraflagellar transport is a bidirectional process that moves molecular cargo along the axoneme, enabling ciliary assembly, signaling, and sensory functions. IFT88 antibody provides researchers with a powerful reagent to study ciliogenesis and cilia mediated signaling pathways in both development and disease.
Mutations in IFT88 cause defects in cilia formation and are associated with a spectrum of ciliopathies, including polycystic kidney disease, retinal degeneration, and skeletal abnormalities. Detection with IFT88 antibody is commonly used in model systems to evaluate cilia integrity and to dissect the molecular mechanisms of ciliary dysfunction. In mice, loss of Ift88 leads to abnormal embryonic development, kidney cysts, and lethality, underscoring the essential nature of this protein for vertebrate survival. In humans, IFT88 mutations have been linked to conditions such as short rib thoracic dysplasia and other syndromes characterized by impaired skeletal growth and organ development.
IFT88 plays a role in Hedgehog signaling, a developmental pathway that depends on intact primary cilia. Studies using IFT88 antibody have revealed its contribution to regulating signal transduction, cell differentiation, and tissue patterning. Aberrant Hedgehog activity linked to ciliary defects highlights the importance of IFT88 in development and disease. This protein is also connected to Wnt signaling and planar cell polarity pathways, expanding its relevance in understanding developmental disorders and congenital anomalies.
IFT88 antibody is useful in western blotting, immunofluorescence, and immunohistochemistry. Immunofluorescence staining of IFT88 localizes the protein to basal bodies and ciliary axonemes, providing spatial resolution of its function. Western blotting identifies protein levels in experimental systems ranging from cultured cells to tissues with high ciliary content. Immunohistochemistry further allows visualization of cilia associated expression in organ samples, including kidney, brain, and respiratory epithelium, making it a valuable tool for diverse biological studies.
Research on ciliopathies, kidney disease, developmental signaling, and structural cell biology relies on validated reagents such as IFT88 antibody. NSJ Bioreagents supports these efforts by supplying antibodies that detect Intraflagellar transport protein 88 with high specificity and reliability, allowing researchers to generate meaningful insights into the biology of cilia and their role in human health and disease. -
UniProt
- Q13099
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途径
- Hedgehog Signaling, Sensory Perception of Sound
抗原
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