Growth Hormone Receptor 抗体
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Quick Overview for Growth Hormone Receptor 抗体 (ABIN7880933)
抗原
See all Growth Hormone Receptor (GHR) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- GHR Antibody / Growth Hormone Receptor
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to human Growth Hormone Receptor / GHR was used as the immunogen for the GHR antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the GHR antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the GHR antibody at -20oC.
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- Growth Hormone Receptor (GHR)
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别名
- GHR
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背景
- The GHR gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. [RefSeq]
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UniProt
- P10912
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途径
- NF-kappaB Signaling, JAK/STAT Signaling, Response to Growth Hormone Stimulus
抗原
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