FADD 抗体
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北京 101111
Quick Overview for FADD 抗体 (ABIN7880765)
抗原
See all FADD 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Fadd Antibody
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序列
- EKENASVAGL VKALRACRLN LVADLVEEAL MAQ
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纯化方法
- Affinity purified
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免疫原
- Amino acids EKENASVAGLVKALRACRLNLVADLVEEALMAQ from the rat protein were used as the immunogen for the Fadd antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Fadd antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Fadd antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
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别名
- Fadd
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背景
- FADD, Fas-Associated protein with Death Domain, is a universal adaptor protein in apoptosis that mediates signaling of all known death domain-containing members of the TNF receptor superfamily. The FADD gene contains 2 exons and spans approximately 3.6 kb. By analysis of somatic cell hybrid panels and by fluorescence in situ hybridization, the FADD gene is mapped to 11q13.3. The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, thus, it participates in the death signaling initiated by these receptors.
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UniProt
- Q8R2E7
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途径
- Apoptosis, TLR signaling, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
抗原
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