EPAS1 抗体
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北京 101111
Quick Overview for EPAS1 抗体 (ABIN7880686)
抗原
See all EPAS1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- HIF2 alpha Antibody
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序列
- SFEPYLLPEL TRYDCEVN
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纯化方法
- Affinity purified
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免疫原
- Amino acids SFEPYLLPELTRYDCEVN from the human protein were used as the immunogen for the HIF2 alpha antibody.
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亚型
- IgG
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anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 21-336) antibody
EPAS1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 339-541) antibodyEPAS1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (Ser343) antibodyEPAS1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 680-870) antibodyEPAS1 适用: 人 IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 1H3E12 unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (C-Term) antibodyEPAS1 适用: 人, 大鼠, 小鼠, 鱼 WB, IHC, ELISA, ICC, IP, FACS, IF, ChIP, EMSA 宿主: 兔 Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 28-347) antibodyEPAS1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G2 unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) antibodyEPAS1 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 535-631) antibodyEPAS1 适用: 人, 大鼠, 小鼠, Hamster WB, IHC, ELISA, ICC, IP, FACS, IF, ChIP 宿主: 小鼠 Monoclonal ep190b unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 1-130) antibodyEPAS1 适用: 人, 大鼠, 小鼠, 猴, 绵羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 400-450) antibodyEPAS1 适用: 人 WB, IHC, ICC, IP, IF/ICC, ChIP 宿主: 兔 Monoclonal BL-95-1A2 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the HIF2 alpha antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the HIF2 alpha antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
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别名
- HIF2 alpha
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背景
- HIF-2 alpha is also designated EPAS1 whose gene is mapped to 2p21-p16. The predicted mouse protein is 88 % identical to human EPAS1. The human EPAS1 gene contains 15 exons and spans at least 120 kb. The positions of the introns within the genomic region encoding the N-terminal bHLH-PAS domains of EPAS1 and AHR are similar, suggesting that the 5-prime ends of the 2 genes may have arisen from a gene duplication event. Moreover, the predicted protein shares 48 % sequence identity with HIF1-alpha, a bHLH-PAS transcription factor that induces EPO gene expression in cultured cells in response to hypoxia. Like HIF1A, EPAS1 binds to and activates transcription from the HIF1A response element derived from the 3-prime flanking region of the EPO gene. EPAS1 is predominantly expressed in highly vascularized tissues of adult humans and in endothelial cells of the mouse adult and embryo. Furthermore, EPAS1 may represent an important regulator of vascularization, perhaps involving the regulation of endothelial cell gene expression in response to hypoxia. HIF2A is expressed at relatively higher levels in villus sections of placenta and in lung samples compared with other tissues examined. In addition, The variation in EPAS1 influences the relative contribution of aerobic and anaerobic metabolism and hence the maximum sustainable metabolic power for a given event duration.
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UniProt
- Q99814
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途径
- Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effect
抗原
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