BIM 抗体
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北京 101111
Quick Overview for BIM 抗体 (ABIN7880062)
抗原
See all BIM (BCL2L11) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- BCL2L11 Antibody / BIM
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to human Bim / BCL2L11 was used as the immunogen for the Bim antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the BCL2L11 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the BCL2L11 antibody at -20oC.
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- BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
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别名
- BCL2L11
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背景
- The protein encoded by the BCL2L11 gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [RefSeq]
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UniProt
- O43521
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途径
- PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity
抗原
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