AMACR 抗体
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北京 101111
Quick Overview for AMACR 抗体 (ABIN7879960)
抗原
See all AMACR 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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原理
- AMACR / p504S Antibody (Prostate Cancer Marker) (azide and preservative free)
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纯化方法
- Protein A affinity
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免疫原
- A synthetic peptide from human AMACR protein was used as the immunogen for the AMACR antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the AMACR antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the AMACR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- AMACR (alpha-Methylacyl-CoA Racemase (AMACR))
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别名
- AMACR / p504S
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背景
- AMACR, also known as p504S, is an enzyme that is involved in bile acid biosynthesis and -oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands. AMACR is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma.
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UniProt
- Q9UHK6
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途径
- Monocarboxylic Acid Catabolic Process
抗原
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