Recombinant PLCB3 抗体 (pSer537)
Our Local Distributor
北京 101111
Quick Overview for Recombinant PLCB3 抗体 (pSer537) (ABIN7879757)
抗原
See all PLCB3 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- pSer537
-
原理
- Phospho-PLCB3 (Ser537) Antibody / Phospholipase C beta 3
-
纯化方法
- Affinity-chromatography
-
免疫原
- A synthesized peptide derived from human Phospho-PLCB3 (S537) was used as the immunogen for the Phospho-PLCB3 (Ser537) antibody.
-
亚型
- IgG
-
-
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (AA 318-468) antibody
PLCB3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (pSer537) antibodyKD Validated PLCB3 适用: 人 WB, ICC 宿主: 兔 Monoclonal 24GB1260 unconjugated Recombinant Antibody
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (AA 1050-1150) antibodyPLCB3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (pSer537) antibodyPLCB3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (pSer537) antibodyPLCB3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (AA 318-468) antibodyPLCB3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (AA 16-50) antibodyPLCB3 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal RB56188 unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (Thr236) antibodyPLCB3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) antibodyPLCB3 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (pSer1105) antibodyPLCB3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the Phospho-PLCB3 (Ser537) antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store the Phospho-PLCB3 (Ser537) antibody at -20oC.
-
-
- PLCB3 (phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3))
-
别名
- PLCB3
-
背景
-
Phospho-PLCB3 (Ser537) antibody detects phospholipase C beta 3 (PLCB3) phosphorylated at serine 537, a modification that regulates enzyme activity and signaling. PLCB3 is a member of the phospholipase C family of enzymes, which hydrolyze phosphatidylinositol 4,5-bisphosphate (PIP2) to generate second messengers inositol trisphosphate (IP3) and diacylglycerol (DAG). These messengers mobilize intracellular calcium and activate protein kinase C, driving pathways involved in cell growth, differentiation, and immune responses.
Research using Phospho-PLCB3 (Ser537) antibody has shown that phosphorylation at this site enhances or modulates enzyme activity depending on cellular context. Kinases including PKC and CaMKII target Ser537, linking feedback regulation to receptor-mediated signaling. This modification influences G protein-coupled receptor (GPCR) and receptor tyrosine kinase pathways, where PLCB3 acts as a critical mediator of calcium signaling.
In immune cells, PLCB3 phosphorylation at Ser537 regulates lymphocyte activation, cytokine production, and inflammatory responses. Dysregulated PLCB3 activity contributes to autoimmune disease, chronic inflammation, and impaired host defense. In cardiovascular research, PLCB3 is implicated in vascular smooth muscle contraction, hypertension, and cardiac hypertrophy. Aberrant PLCB3 signaling has also been linked to tumorigenesis, where altered calcium signaling drives proliferation and survival.
Neurobiology studies show that PLCB3 contributes to synaptic plasticity and neurotransmitter release, with Ser537 phosphorylation fine-tuning neuronal calcium dynamics. This role connects PLCB3 to learning, memory, and neurological disorders. In endocrine systems, PLCB3 signaling regulates hormone secretion and metabolic processes.
Antibodies against phospho-PLCB3 (Ser537) are validated for western blot, immunohistochemistry, and immunofluorescence. These reagents allow detection of phosphorylation-dependent activation, supporting studies in signaling pathways and disease models.
NSJ Bioreagents supplies this Phospho-PLCB3 (Ser537) antibody for research into calcium signaling, immunity, and cancer biology. -
UniProt
- Q01970
-
途径
- WNT signaling, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, CXCR4-mediated Signaling Events, G-protein mediated Events
抗原
-
