PARL 抗体 (Middle Region)
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北京 101111
Quick Overview for PARL 抗体 (Middle Region) (ABIN7879543)
抗原
See all PARL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- PARL Antibody / Presenilins-associated rhomboid-like protein
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human PARL was used as the immunogen for the PARL antibody.
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亚型
- IgG
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anti-Presenilin Associated, Rhomboid-Like (PARL) (N-Term) antibody
PARL 适用: 人, 小鼠, 大鼠, 犬, 马, Pig, 兔, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (N-Term) antibodyPARL 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 1-170) antibodyPARL 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 97-146) antibodyPARL 适用: 人, 小鼠, 大鼠, 犬, 马, Pig, 兔, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 112-167) antibodyPARL 适用: 人 ELISA 宿主: 小鼠 Monoclonal 8C4B2 unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 2-100) antibodyPARL 适用: 人 ELISA 宿主: 小鼠 Monoclonal 4F4 unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 1-170) antibodyPARL 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (N-Term) antibodyPARL 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PARL antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PARL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PARL (Presenilin Associated, Rhomboid-Like (PARL))
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别名
- PARL
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背景
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PARL antibody detects Presenilins-associated rhomboid-like protein, a mitochondrial intramembrane protease involved in regulating mitochondrial dynamics, apoptosis, and mitophagy. The UniProt recommended name is Presenilins-associated rhomboid-like protein (PARL). This serine protease participates in the regulated intramembrane proteolysis of substrates that control mitochondrial morphology and quality control.
Functionally, PARL antibody identifies a 379-amino-acid protein localized to the inner mitochondrial membrane. PARL cleaves and activates key mitochondrial substrates such as PINK1 and PGAM5, initiating mitophagy and apoptosis signaling pathways. Through these actions, PARL maintains mitochondrial homeostasis and protects cells from oxidative stress. It also participates in remodeling the inner membrane during stress conditions, influencing cristae organization and mitochondrial fission-fusion balance.
The PARL gene is located on chromosome 3q27.1 and is expressed in metabolically active tissues including brain, heart, and skeletal muscle. Expression levels fluctuate with energy demand and stress, with upregulation observed during mitochondrial biogenesis and differentiation. PARL is evolutionarily conserved across eukaryotes, emphasizing its fundamental role in organelle maintenance.
Pathologically, mutations in PARL have been associated with mitochondrial dysfunction, Parkinson's disease, and metabolic disorders. Impaired PARL activity disrupts PINK1 processing, leading to defective mitophagy and accumulation of damaged mitochondria. In contrast, overexpression may alter apoptotic sensitivity by influencing cytochrome c release. Research using PARL antibody supports studies in mitochondrial biology, apoptosis regulation, and neurodegenerative disease.
PARL antibody can be validated for western blotting, immunofluorescence, and immunohistochemistry to detect mitochondrial proteases. NSJ Bioreagents provides PARL antibody reagents optimized for research in mitophagy, proteolytic signaling, and mitochondrial quality control.
Structurally, Presenilins-associated rhomboid-like protein contains seven transmembrane domains forming a proteolytic chamber within the inner mitochondrial membrane. Its catalytic serine and histidine residues form the rhomboid protease active site. The protein's C-terminal region undergoes regulated processing, modulating its activity in stress conditions. This antibody enables investigation of PARL's role in mitochondrial proteostasis and apoptosis signaling. -
UniProt
- Q9H300
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途径
- Autophagy
抗原
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