CD42a 抗体 (Middle Region)
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Quick Overview for CD42a 抗体 (Middle Region) (ABIN7879522)
抗原
See all CD42a (GP9) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- Glycoprotein 9 Antibody / Gp9 / CD42a
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human CD42a/GP9 was used as the immunogen for the Glycoprotein 9 antibody.
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亚型
- IgG
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anti-Glycoprotein IX (Platelet) (GP9) (AA 1-189) antibody
GP9 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein IX (Platelet) (GP9) (AA 17-147) antibodyGP9 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 4E2G7 unconjugated
anti-Glycoprotein IX (Platelet) (GP9) antibody (FITC)GP9 适用: 人, 犬 FACS 宿主: 小鼠 Monoclonal GR-P FITC
anti-Glycoprotein IX (Platelet) (GP9) (AA 17-88) antibodyGP9 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein IX (Platelet) (GP9) antibodyGP9 适用: 人, 犬 FACS 宿主: 小鼠 Monoclonal GR-P unconjugated
anti-Glycoprotein IX (Platelet) (GP9) antibody (APC)GP9 适用: 人, 犬 FACS 宿主: 小鼠 Monoclonal GR-P APC
anti-Glycoprotein IX (Platelet) (GP9) antibody (PE)GP9 适用: 人, 犬, Mink FACS 宿主: 小鼠 Monoclonal GRP-P PE
anti-Glycoprotein IX (Platelet) (GP9) (AA 1-177) antibodyGP9 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Glycoprotein IX (Platelet) (GP9) (Internal Region) antibodyGP9 适用: 人, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein IX (Platelet) (GP9) (AA 17-147) antibodyGP9 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Glycoprotein 9 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Glycoprotein 9 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- CD42a (GP9) (Glycoprotein IX (Platelet) (GP9))
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别名
- Glycoprotein 9
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背景
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Glycoprotein 9 antibody detects Platelet glycoprotein IX, a membrane glycoprotein that forms part of the GPIb-IX-V complex essential for platelet adhesion and thrombus formation. Glycoprotein 9 functions as a structural subunit that stabilizes the GPIbalpha receptor, enabling platelet interaction with von Willebrand factor under high shear conditions. The Glycoprotein 9 antibody is widely used in hematology and cardiovascular research to study platelet function, coagulation, and bleeding disorders.
The protein is encoded by the GP9 gene on human chromosome 3q21.3. Glycoprotein 9 is approximately 177 amino acids long and contains a single leucine-rich repeat flanked by cysteine-rich regions, which maintain receptor conformation and complex assembly. It is expressed exclusively on platelet membranes and megakaryocytes, where it associates non-covalently with GPIbalpha and GPIbbeta to form the functional receptor complex for von Willebrand factor binding.
The Glycoprotein 9 antibody detects a 25 kilodalton band by western blot and shows strong membrane staining in platelets. The GPIb-IX-V complex mediates platelet tethering to exposed subendothelial matrix at sites of vascular injury, initiating platelet activation and aggregation. Defects or mutations in Glycoprotein 9 lead to Bernard-Soulier syndrome, characterized by thrombocytopenia, giant platelets, and impaired adhesion.
Beyond hemostasis, the GPIb-IX-V complex participates in inflammatory and immune signaling. Platelet Glycoprotein 9 contributes to leukocyte recruitment, vascular permeability, and thromboinflammatory responses. Overexpression or dysregulation has been associated with thrombosis and cardiovascular disease, making it an important target for antithrombotic therapy.
Because of its role in platelet adhesion and vascular integrity, Glycoprotein 9 is a critical biomarker for platelet-related disorders. NSJ Bioreagents provides a validated Glycoprotein 9 antibody optimized for its applications, supporting research into hemostasis, thrombosis, and vascular inflammation. -
UniProt
- P14770
抗原
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