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CD42a 抗体

GP9 适用: 人, 犬 FACS 宿主: 小鼠 Monoclonal GR-P unconjugated
产品编号 ABIN1981875
发货至: 中国
  • 抗原 See all CD42a (GP9) 抗体
    CD42a (GP9) (Glycoprotein IX (Platelet) (GP9))
    适用
    • 60
    • 12
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 犬
    宿主
    • 41
    • 22
    小鼠
    克隆类型
    • 43
    • 20
    单克隆
    标记
    • 25
    • 9
    • 6
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD42a antibody is un-conjugated
    应用范围
    • 26
    • 24
    • 19
    • 14
    • 13
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    特异性
    The mouse monoclonal antibody GR-P (also known as GRP-P) recognizes an extracellular epitope of CD42a (glycoprotein 9), a 22 kDa transmembrane protein constitutively expressed on megakaryocytes and platelets.
    交叉反应 (详细)
    Human, Canine (Dog)
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Human acute lymphoblastic leukemia cells
    克隆位点
    GR-P
    亚型
    IgG1
    Top Product
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  • 应用备注
    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze. Do not use after expiration date stamped on vial label.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • Din, Aftab, Jubb, Carnegy, Lyall, Sarma, Newby, Flapan: "Effect of moderate walnut consumption on lipid profile, arterial stiffness and platelet activation in humans." in: European journal of clinical nutrition, Vol. 65, Issue 2, pp. 234-9, (2011) (PubMed).

    Harding, Din, Sarma, Josephs, Fox, Newby: "Promotion of proinflammatory interactions between platelets and monocytes by unfractionated heparin." in: Heart (British Cardiac Society), Vol. 92, Issue 11, pp. 1635-8, (2006) (PubMed).

    Brown, Clarke, Magowan, Sanderson, Savill: "Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase-independent cell clearance program." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5987-96, (2000) (PubMed).

  • 抗原
    CD42a (GP9) (Glycoprotein IX (Platelet) (GP9))
    别名
    CD42a (GP9 产品)
    别名
    cd42a antibody, gpix antibody, GP9 antibody, GPIX antibody, Cd42 antibody, CD42a antibody, glycoprotein IX platelet antibody, glycoprotein IX platelet L homeolog antibody, glycoprotein IX (platelet) antibody, glycoprotein 9 (platelet) antibody, GP9 antibody, gp9.L antibody, Gp9 antibody
    背景
    Glycoprotein IX platelet,CD42a, also known as glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.,GPIX, GP9
    基因ID
    2815
    UniProt
    P14770
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