FASL 抗体 (Middle Region)
Our Local Distributor
北京 101111
Quick Overview for FASL 抗体 (Middle Region) (ABIN7879516)
抗原
See all FASL 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Middle Region
-
原理
- FASLG Antibody / FASL / Fas ligand
-
纯化方法
- Immunogen affinity purified
-
免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human FASL/FASLG was used as the immunogen for the FASLG antibody.
-
亚型
- IgG
-
-
anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 196-281) antibody
FASL 适用: 人, 小鼠, 大鼠, Pig WB, FACS, ELISA, ICC, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 100-200) antibodyFASL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) antibodyFASL 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 102-280) antibodyFASL 适用: 猕猴 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 100-278) antibodyFASL 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 82-145) antibodyFASL 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 1-281) antibodyFASL 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2G9-G8 unconjugated
anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 103-281) antibodyFASL 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) antibodyFASL 适用: 人 WB, FACS, IP, ICC, Func 宿主: 小鼠 Monoclonal NOK-1 unconjugated
anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) antibodyFASL 适用: 人 WB, FACS, IP, ICC 宿主: 小鼠 Monoclonal NOK-1 unconjugated
-
-
应用备注
- Optimal dilution of the FASLG antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the FASLG antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))
-
别名
- FASLG
-
背景
-
FASLG antibody detects Fas ligand, encoded by the FASLG gene on chromosome 1q23. FASLG antibody is widely applied in apoptosis, immune regulation, and cancer biology. Fas ligand is a type II transmembrane protein belonging to the TNF superfamily that induces apoptosis by binding its receptor Fas (CD95). This ligand-receptor interaction is essential for immune homeostasis, cytotoxic T cell function, and elimination of damaged or malignant cells.
Structurally, Fas ligand is a ~40 kDa protein with a short cytoplasmic tail, a transmembrane region, and a TNF homology domain that mediates trimerization and receptor binding. Fas ligand exists in membrane-bound and soluble forms, the latter generated by proteolytic cleavage. Membrane-bound Fas ligand is the primary inducer of apoptosis, whereas soluble Fas ligand modulates immune signaling and inflammation.
Functionally, Fas ligand is expressed on activated T cells, NK cells, and certain tissues. Engagement of Fas receptor by Fas ligand recruits FADD and initiates caspase-8 activation, leading to apoptosis. Beyond apoptosis, Fas ligand contributes to immune privilege, inflammation, and tissue injury. Researchers use FASLG antibody to study apoptosis, cytotoxic lymphocyte activity, and immune regulation.
Clinically, mutations in FASLG cause autoimmune lymphoproliferative syndrome (ALPS), characterized by defective lymphocyte apoptosis. Dysregulation of Fas ligand contributes to autoimmune disease, transplant rejection, and cancer immune evasion. Tumors exploit Fas ligand expression to induce apoptosis of infiltrating immune cells, aiding immune escape. Because of its dual roles in immune surveillance and pathology, Fas ligand is a target for therapeutic modulation. NSJ Bioreagents supplies FASLG antibody for immunology, apoptosis, and cancer studies.
Experimentally, FASLG antibody is applied in western blotting to detect the ~40 kDa protein, in flow cytometry to measure surface expression, and in immunohistochemistry to study tissue-specific regulation. Functional assays using FASLG antibody evaluate apoptosis induction in cell models. -
UniProt
- P48023
-
途径
- Apoptosis, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
抗原
-
