ube3a 抗体 (full length)
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北京 101111
Quick Overview for ube3a 抗体 (full length) (ABIN7879290)
抗原
See all ube3a 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- full length
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原理
- Ubiquitin-protein ligase E3A Antibody / UBE3A
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant full-length human UBE3A protein was used as the immunogen for the Ubiquitin-protein ligase E3A antibody.
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亚型
- IgG1
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anti-Ubiquitin Protein Ligase E3A (ube3a) (AA 51-150) antibody
ube3a 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2F6 unconjugated
anti-Ubiquitin Protein Ligase E3A (ube3a) antibodyube3a 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3A (ube3a) (AA 836-865), (C-Term) antibodyube3a 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB4440 unconjugated
anti-Ubiquitin Protein Ligase E3A (ube3a) (AA 1-860) antibodyube3a 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3A (ube3a) antibodyube3a 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3A (ube3a) (AA 300-590) antibodyube3a 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3A (ube3a) antibodyKD Validated ube3a 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB1620 unconjugated
anti-Ubiquitin Protein Ligase E3A (ube3a) (Middle Region) antibodyube3a 适用: 人, 小鼠, 大鼠, 兔, 犬, 豚鼠, 马, 斑马鱼, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3A (ube3a) (AA 83-234) antibodyube3a 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3A (ube3a) antibodyube3a 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB4775 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the Ubiquitin-protein ligase E3A antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Ubiquitin-protein ligase E3A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- ube3a (Ubiquitin Protein Ligase E3A (ube3a))
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别名
- Ubiquitin-protein ligase E3A
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背景
- E6-associating protein (E6-AP), also designated ubiquitin protein ligase E3A (UBE3A), is a component of the ubiquitin-mediated proteolytic pathway that selectively targets proteins for degradation by the 26S Proteasome. Ubiquitin(Ub) is directly conjugated to protein substrates by the transfer of Ub from anE2 ubiquitin conjugating enzyme to the target protein. This conjugation is facilitated by the enzymatic activity of E3 ubiquitin ligase family members such asE6-AP. Several substrates of E6-AP have been identified and include the tumor suppressor protein p53 and the mammalian homolog of Rad23, HHR23A.Previous studies have indicated that E6-AP associates with the human papilloma virus E6 oncogene, which forms a complex with p53 and there by potentiates E6-AP mediated ubiquitination of p53. Genetic mutations that impair E6-AP activity result in the accumulation of p53 in the cytoplasm, and in many instances, these mutations are associated with the development of the rare neurodevelopmental disorder Angelman syndrome (AS), which is characterized by severe motor dysfunction and mental retardation.
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UniProt
- Q05086
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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