NOD1 抗体 (AA 923-951)
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Quick Overview for NOD1 抗体 (AA 923-951) (ABIN7877174)
抗原
See all NOD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 923-951
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原理
- NOD1 Antibody
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 923-951 from the human protein was used as the immunogen for the NOD1 antibody.
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亚型
- IgG
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应用备注
- The stated application concentrations are suggested starting points. Titration of the NOD1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the NOD1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- NOD1 (Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1))
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别名
- NOD1
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背景
- This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined.
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UniProt
- Q9Y239
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途径
- Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades, Inflammasome
抗原
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