Plakophilin 2 抗体 (AA 9-866)
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Quick Overview for Plakophilin 2 抗体 (AA 9-866) (ABIN7877099)
抗原
See all Plakophilin 2 (PKP2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 9-866
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原理
- PKP2 Antibody / Plakophilin 2
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纯化方法
- Antigen affinity purified
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免疫原
- E. coli-derived recombinant mouse protein (amino acids E9-D866) was used as the immunogen for the PKP2 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the PKP2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PKP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Plakophilin 2 (PKP2)
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别名
- PKP2
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背景
- Plakophilin-2 is a protein that in humans is encoded by the PKP2 gene. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene may regulate the signaling activity of beta-catenin and is required to maintain transcription of genes that control intracellular calcium cycling including ryanodine receptor 2, ankyrin-B, triadin, and calcium channel, voltage-dependent, L type, alpha 1C. Mutations in this gene are associated with different inherited cardiac conditions including Arrythmogenic Cardiomyopathy, Brugada Syndrome, and Idiopathic Ventricular Fibrillation. A processed pseudogene with high similarity to this gene has been mapped to chromosome 12p13.
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UniProt
- Q99959
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途径
- Cell-Cell Junction Organization, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
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