INHBA 抗体 (AA 85-112)
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Quick Overview for INHBA 抗体 (AA 85-112) (ABIN7876968)
抗原
See all INHBA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 85-112
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原理
- Inhibin beta A chain Antibody / INHBA
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 85-112 from the human protein was used as the immunogen for the Inhibin beta A chain antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the Inhibin beta A chain antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Inhibin beta A chain antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- INHBA (Inhibin, beta A (INHBA))
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别名
- Inhibin beta A chain
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背景
- The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
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UniProt
- P08476
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途径
- Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Autophagy
抗原
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