KPNB1 抗体 (AA 8-876)
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Quick Overview for KPNB1 抗体 (AA 8-876) (ABIN7876847)
抗原
See all KPNB1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 8-876
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原理
- KPNB1 Antibody / Importin subunit beta 1
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids E8-A876) was used as the immunogen for the KPNB1 antibody.
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亚型
- IgG2b
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应用备注
- Optimal dilution of the KPNB1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the KPNB1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))
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别名
- KPNB1
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背景
- Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene. Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene.
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UniProt
- Q14974
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途径
- Protein targeting to Nucleus
抗原
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