SMURF1 抗体 (AA 66-96)
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Quick Overview for SMURF1 抗体 (AA 66-96) (ABIN7876356)
抗原
See all SMURF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 66-96
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原理
- SMURF1 Antibody
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纯化方法
- Purified
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免疫原
- A portion of amino acids 66-96 from the human protein was used as the immunogen for the SMURF1 antibody.
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亚型
- Ig Fraction
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anti-SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) (AA 165-268) antibody
SMURF1 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 1D7 unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) (AA 198-374) antibodySMURF1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) (AA 66-96), (N-Term) antibodySMURF1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB04101 unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) antibodySMURF1 适用: 人, 小鼠 WB, IF, IHC (p), EIA, IP 宿主: 小鼠 Monoclonal 1D7 unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) (AA 711-740), (C-Term) antibodySMURF1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4103 unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) (AA 1-731) antibodySMURF1 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) (AA 165-269) antibodySMURF1 适用: 人, 小鼠 WB, ELISA, IHC, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 1D7 unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) (AA 66-96) antibodySMURF1 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) (N-Term) antibodySMURF1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) (AA 165-268) antibodySMURF1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- The stated application concentrations are suggested starting points. Titration of the SMURF1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the SMURF1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1))
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别名
- SMURF1
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背景
- Members of the transforming growth factor-beta (TGFB) family signal through type I and type II serine/threonine-kinase receptors, which in turn activate the SMAD signaling pathway. Bone morphogenetic protein (BMP) receptors target SMAD1, SMAD5, and SMAD8, whereas receptors for activin and TGFB (e.g., ACVR1 and TGFBR1, respectively) target SMAD2 and SMAD3. Phosphorylation of these receptor-regulated SMADs induces their association with the common-partner SMAD, SMAD4. Smurf1, a HECT domain E3 ubiquitin ligase, regulates cell polarity and protrusive activity and is required to maintain the transformed morphology and motility of a tumor cell. Atypical protein kinase C-zeta (PKC2), an effector of the Cdc42/Rac1-PAR6 polarity complex, recruits Smurf1 to cellular protrusions, where it controlled the local level of RhoA. Smurf1 thus links the polarity complex to degradation of RhoA in lamellipodia and filopodia to prevent RhoA signaling during dynamic membrane movements.
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UniProt
- Q9HCE7
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途径
- Regulation of Cell Size
抗原
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