Recombinant BAP1 抗体 (AA 630-729)
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Quick Overview for Recombinant BAP1 抗体 (AA 630-729) (ABIN7876243)
抗原
See all BAP1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 630-729
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原理
- BRCA1-Associated Protein 1 Antibody / BAP1
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein sequence (within amino acids 630-729) from the human protein was used as the immunogen for the BRCA1-Associated Protein 1 antibody.
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亚型
- IgG, kappa
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应用备注
- Optimal dilution of the BRCA1-Associated Protein 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the BRCA1-Associated Protein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))
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别名
- BRCA1-Associated Protein 1
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背景
- The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.
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UniProt
- Q92560
抗原
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