BAP1 抗体 (pSer592)
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北京 101111
Quick Overview for BAP1 抗体 (pSer592) (ABIN6256382)
抗原
See all BAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer592
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原理
- Phospho-BAP1 (Ser592) Antibody
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特异性
- Phospho-BAP1 (Ser592) Antibody detects endogenous levels of BAP1.
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预测反应
- Bovine,Horse,Sheep
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纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
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免疫原
- A synthesized peptide derived from human BAP1 around the phosphorylation site of Ser592.
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亚型
- IgG
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anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) (AA 36-66) antibody
BAP1 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal RB4559-4560 unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) (AA 475-525) antibodyBAP1 适用: 人, 小鼠 WB, IHC, IP, ICC 宿主: 兔 Monoclonal BLR372N unconjugated Recombinant Antibody
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) (AA 475-525) antibodyBAP1 适用: 人, 小鼠 WB, IHC, IP, ICC 宿主: 兔 Monoclonal BLR372N unconjugated Recombinant Antibody
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) (AA 460-729) antibodyBAP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) antibodyBAP1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) (pSer592) antibodyBAP1 适用: 人 IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) (AA 191-326) antibodyBAP1 适用: 人 ELISA 宿主: 小鼠 Monoclonal BAP1-2431 unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) (AA 679-729) antibodyBAP1 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) antibodyKO Validated BAP1 适用: 人 WB 宿主: 兔 Monoclonal 25GB3670 unconjugated Recombinant Antibody
anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) (AA 1-729) antibodyBAP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))
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别名
- BAP1
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背景
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Description: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.
Gene: BAP1
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分子量
- 95kDa
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基因ID
- 8314
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UniProt
- Q92560
抗原
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