HBEGF 抗体 (AA 63-148)
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Quick Overview for HBEGF 抗体 (AA 63-148) (ABIN7876206)
抗原
See all HBEGF 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 63-148
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原理
- Dtr Antibody / Hbegf
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纯化方法
- Antigen affinity purified
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免疫原
- An E.coli-derived mouse recombinant protein (D63-L148) was used as the immunogen for the Dtr antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Dtr antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Dtr antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))
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别名
- Dtr
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背景
- Heparin-binding EGF-like growth factor (HB-EGF), also called Diphtheria toxin receptor (Dtr) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. Enables epidermal growth factor receptor binding activity, growth factor activity, and heparin binding activity. Involved in positive regulation of keratinocyte migration, positive regulation of smooth muscle cell proliferation, and wound healing, spreading of epidermal cells. Acts upstream of or within several processes, including epidermal growth factor receptor signaling pathway, positive regulation of peptidyl-tyrosine phosphorylation, and regulation of heart contraction. Located in extracellular space. Is integral component of plasma membrane. Is expressed in several structures, including branchial arch, heart, oral region gland, telencephalon, and tooth. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor).
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UniProt
- Q06186
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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