alpha 2 Macroglobulin 抗体 (AA 604-748)
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Quick Overview for alpha 2 Macroglobulin 抗体 (AA 604-748) (ABIN7876083)
抗原
See all alpha 2 Macroglobulin (A2M) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 604-748
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原理
- Alpha-2-Macroglobulin Antibody / A2M
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纯化方法
- Protein A/G affinity
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免疫原
- A human recombinant A2M protein fragment (within amino acids 604-748) was used as the immunogen for the Alpha-2-Macroglobulin antibody.
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亚型
- IgG1, kappa
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anti-alpha-2-Macroglobulin (A2M) antibody
A2M 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-alpha-2-Macroglobulin (A2M) (AA 616-856) antibodyA2M 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-alpha-2-Macroglobulin (A2M) (AA 616-856) antibodyA2M 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C6 unconjugated
anti-alpha-2-Macroglobulin (A2M) (AA 1053-1214) antibodyA2M 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-alpha-2-Macroglobulin (A2M) (AA 1216-1467) antibodyA2M 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-alpha-2-Macroglobulin (A2M) antibodyA2M 适用: 人 WB, IHC, IP, ELISA, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-alpha-2-Macroglobulin (A2M) (AA 1-1474) antibodyA2M 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-alpha-2-Macroglobulin (A2M) (AA 641-730) antibodyA2M 适用: 人 ELISA, PLA 宿主: 小鼠 Monoclonal 2B5 unconjugated
anti-alpha-2-Macroglobulin (A2M) antibodyA2M 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-alpha-2-Macroglobulin (A2M) (C-Term) antibodyA2M 适用: 人, 大鼠 WB, IHC, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Alpha-2-Macroglobulin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles
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储存条件
- -20 °C
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储存方法
- Aliquot the Alpha-2-Macroglobulin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))
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别名
- Alpha-2-Macroglobulin
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背景
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Alpha-2-Macroglobulin antibody targets Alpha-2-Macroglobulin, a large secreted plasma glycoprotein encoded by the A2M gene and a major component of the innate protease inhibition system. Alpha-2-Macroglobulin functions as a broad-spectrum protease inhibitor capable of trapping and inactivating a wide range of proteases, including serine, cysteine, aspartic, and metalloproteases. Through this mechanism, Alpha-2-Macroglobulin plays a critical role in regulating proteolysis, inflammation, and tissue remodeling.
Alpha-2-Macroglobulin is synthesized primarily by hepatocytes and secreted into the bloodstream, where it circulates at high concentrations. It is also produced locally by macrophages, fibroblasts, and certain epithelial cells under inflammatory or stress conditions. As a soluble extracellular protein, Alpha-2-Macroglobulin interacts with proteases via a bait region that triggers a conformational change, physically entrapping the protease and targeting the complex for clearance through receptor-mediated endocytosis. A2M antibody detection is therefore relevant for studies of extracellular protease regulation and immune surveillance.
Beyond protease inhibition, Alpha-2-Macroglobulin functions as a carrier protein for cytokines, growth factors, and hormones, including transforming growth factor beta and basic fibroblast growth factor. By binding and modulating the bioavailability of these signaling molecules, Alpha-2-Macroglobulin influences processes such as cell proliferation, wound healing, and immune responses. A2M antibody reagents support investigations into how protease control intersects with growth factor signaling and inflammatory regulation.
Dysregulation of Alpha-2-Macroglobulin expression or function has been associated with numerous disease states. Altered A2M levels have been reported in liver disease, neurodegenerative disorders, cardiovascular disease, and cancer. In the nervous system, Alpha-2-Macroglobulin has been implicated in amyloid beta clearance and neuroinflammation, while in oncology it may influence tumor progression by modulating protease activity within the tumor microenvironment. These diverse biological roles underscore the value of A2M antibody-based detection in both basic and translational research.
Clone A2M/6553 is designed to recognize Alpha-2-Macroglobulin in research applications. Alpha-2-Macroglobulin antibody reagents are suitable for detecting protein expression and distribution in serum, tissues, and cell-derived samples, supporting studies focused on protease regulation, inflammatory processes, and disease-associated alterations in extracellular protein homeostasis. -
UniProt
- P01023
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途径
- Lipid Metabolism
抗原
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