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alpha Sarcomeric Actin (AA 557-692) 抗体

This 小鼠 单克隆 antibody specifically detects alpha Sarcomeric Actin in IHC (p) 和 WB. It exhibits reactivity toward 人.
产品编号 ABIN7875749
发货至: 中国
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Quick Overview for alpha Sarcomeric Actin (AA 557-692) 抗体 (ABIN7875749)

抗原

alpha Sarcomeric Actin

适用

  • 8
  • 1
  • 1
人

宿主

  • 5
  • 4
小鼠

克隆类型

  • 7
  • 2
单克隆

标记

  • 9
非结合性

应用范围

  • 7
  • 5
  • 2
  • 1
  • 1
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

克隆位点

ACTN2-3293
  • 抗原表位

    • 7
    • 1
    AA 557-692

    原理

    Sarcomeric Alpha Actinin Antibody / ACTN2

    纯化方法

    Protein G affinity chromatography

    免疫原

    Amino acids 557-692 from the human protein were used as the immunogen for this Sarcomeric Alpha Actinin antibody.

    亚型

    IgG1, kappa
  • 应用备注

    The optimal dilution of the Sarcomeric Alpha Actinin antibody for each application should be determined by the researcher.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store the Sarcomeric Alpha Actinin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    alpha Sarcomeric Actin

    别名

    Sarcomeric Alpha Actinin

    背景

    Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.

    UniProt

    P35609
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