SSH1 抗体 (AA 489-921)
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Quick Overview for SSH1 抗体 (AA 489-921) (ABIN7875236)
抗原
See all SSH1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 489-921
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原理
- SSH1 Antibody / Slingshot protein phosphatase 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SSH1 recombinant protein (Position: E489-Y921) was used as the immunogen for the SSH1 antibody.
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亚型
- IgG
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anti-Slingshot Homolog 1 (SSH1) (AA 752-849) antibody
SSH1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F9 unconjugated
anti-Slingshot Homolog 1 (SSH1) (AA 950-1049) antibodySSH1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1D2 unconjugated
anti-Slingshot Homolog 1 (SSH1) (AA 1032-1044) antibodySSH1 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 6C11G9 unconjugated
anti-Slingshot Homolog 1 (SSH1) (AA 1032-1044) antibodySSH1 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 1A5C8 unconjugated
anti-Slingshot Homolog 1 (SSH1) (AA 928-1049) antibodySSH1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Slingshot Homolog 1 (SSH1) (AA 227-254), (N-Term) antibodySSH1 适用: 人 WB 宿主: 兔 Polyclonal RB40522 unconjugated
anti-Slingshot Homolog 1 (SSH1) (AA 1-1049) antibodySSH1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Slingshot Homolog 1 (SSH1) (AA 1-1049) antibodySSH1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Slingshot Homolog 1 (SSH1) (AA 999-1049) antibodySSH1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SSH1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SSH1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SSH1 (Slingshot Homolog 1 (SSH1))
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别名
- SSH1
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背景
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SSH1 antibody detects Slingshot protein phosphatase 1, a serine/threonine phosphatase that regulates actin filament dynamics by dephosphorylating cofilin. The UniProt recommended name is Slingshot protein phosphatase 1 (SSH1). This cytoplasmic enzyme is crucial for actin cytoskeleton remodeling during cell motility, adhesion, and morphogenesis.
Functionally, SSH1 antibody identifies a 1,047-amino-acid phosphatase that activates cofilin by removing inhibitory phosphate groups at serine 3. SSH1 operates downstream of Rho family GTPases and is controlled by 14-3-3 proteins, oxidative signals, and phosphorylation. It promotes lamellipodia formation and cytoskeletal reorganization during migration and neuronal outgrowth.
The SSH1 gene is located on chromosome 12q24.13 and is expressed in brain, muscle, and epithelial tissues. SSH1 integrates signals from LIM kinase and Rac/Cdc42 pathways to coordinate actin turnover and filament severing. Through cofilin activation, SSH1 drives rapid actin recycling necessary for directional movement and cell shape maintenance.
Pathologically, altered SSH1 activity contributes to cancer metastasis, neurological disorders, and cardiac hypertrophy. Dysregulated actin remodeling via SSH1-cofilin imbalance leads to defective migration and cytoskeletal instability. Research using SSH1 antibody supports studies in cytoskeletal dynamics, phosphatase signaling, and cell motility.
SSH1 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect actin-regulating phosphatases. NSJ Bioreagents provides SSH1 antibody reagents optimized for studies in cell migration, cytoskeletal remodeling, and signal transduction.
Structurally, Slingshot protein phosphatase 1 contains an N-terminal cofilin-binding region and a catalytic domain related to the dual-specificity phosphatase family. This antibody aids in analyzing SSH1's control over actin filament turnover and cellular movement. -
UniProt
- Q8WYL5
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途径
- CXCR4-mediated Signaling Events
抗原
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