RNF34 抗体 (AA 46-372)
Our Local Distributor
北京 101111
Quick Overview for RNF34 抗体 (AA 46-372) (ABIN7875119)
抗原
See all RNF34 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 46-372
-
原理
- RNF34 Antibody / hRFI / CARP-1
-
纯化方法
- Antigen affinity purified
-
免疫原
- E. coli-derived recombinant human protein (amino acids E46-S372) was used as the immunogen for the RNF34 antibody.
-
亚型
- IgG
-
-
anti-Ring Finger Protein 34 (RNF34) (AA 1-373) antibody
RNF34 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 34 (RNF34) (AA 1-220) antibodyRNF34 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 34 (RNF34) (AA 143-192) antibodyRNF34 适用: 人, Cow, 兔, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 34 (RNF34) (Middle Region) antibodyRNF34 适用: 人, Cow, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the RNF34 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the RNF34 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- RNF34 (Ring Finger Protein 34 (RNF34))
-
别名
- RNF34
-
背景
- E3 ubiquitin-protein ligase RNF34, also called Human RING finger homologous to inhibitor of apoptosis protein (hRFI) and Caspases-8 and -10-associated RING finger protein 1 (CARP-1) is an enzyme that in humans is encoded by the RNF34 gene. The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms.
-
UniProt
- Q969K3
抗原
-
