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COX2 抗体 (AA 442-572)

The 小鼠 单克隆 anti-COX2 antibody (Clone COX2-2377) (ABIN7875031) specifically detects COX2 in IHC (p). The antibody is reactive with 人 samples.
产品编号 ABIN7875031
发货至: 中国
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Quick Overview for COX2 抗体 (AA 442-572) (ABIN7875031)

抗原

See all COX2 抗体
COX2 (Cytochrome C Oxidase Subunit II (COX2))

适用

  • 106
  • 37
  • 13
  • 1

宿主

  • 104
  • 9
  • 2
小鼠

克隆类型

  • 61
  • 54
单克隆

标记

  • 53
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 4
  • 4
  • 2
  • 1
  • 1
  • 1
This COX2 antibody is un-conjugated

应用范围

  • 81
  • 54
  • 32
  • 26
  • 25
  • 19
  • 15
  • 11
  • 4
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

COX2-2377
  • 抗原表位

    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 442-572

    原理

    COX2 Antibody / PTGS2

    纯化方法

    Protein A/G affinity

    免疫原

    A portion of amino acids 442-572 was used as the immunogen for the COX2 antibody.

    亚型

    IgG2a, kappa
  • 应用备注

    Optimal dilution of the COX2 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the COX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    COX2 (Cytochrome C Oxidase Subunit II (COX2))

    别名

    COX2

    背景

    Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (COX2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and COX2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. COX2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90 % of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.

    UniProt

    P35354

    途径

    Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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