GIT1 抗体 (AA 415-736)
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北京 101111
Quick Overview for GIT1 抗体 (AA 415-736) (ABIN7874885)
抗原
See all GIT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 415-736
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原理
- GIT1 Antibody / p95-APP1
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids D415-Q736) was used as the immunogen for the GIT1 antibody.
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亚型
- IgG
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anti-GIT1 (GIT1) (AA 460-640) antibody
KO Validated GIT1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-GIT1 (GIT1) (AA 415-736) antibodyGIT1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-GIT1 (GIT1) (AA 533-561), (C-Term), (Tyr554) antibodyGIT1 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB15351 unconjugated
anti-GIT1 (GIT1) (AA 470-642) antibodyGIT1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-GIT1 (GIT1) (Internal Region) antibodyGIT1 适用: 人, 大鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-GIT1 (GIT1) (AA 375-770) antibody (Atto 390)GIT1 适用: 大鼠 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal S39B-8 Atto 390
anti-GIT1 (GIT1) (AA 375-770) antibody (Atto 488)GIT1 适用: 大鼠 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal S39B-8 Atto 488
anti-GIT1 (GIT1) (AA 375-770) antibody (Atto 594)GIT1 适用: 大鼠 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal S39B-8 Atto 594
anti-GIT1 (GIT1) (AA 375-770) antibody (PerCP)GIT1 适用: 大鼠 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal S39B-8 PerCP
anti-GIT1 (GIT1) (AA 375-770) antibody (PE)GIT1 适用: 大鼠 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal S39B-8 PE
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应用备注
- Optimal dilution of the GIT1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GIT1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GIT1
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别名
- GIT1
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背景
- ARF GTPase-activating protein GIT1 is an enzyme that in humans is encoded by the GIT1 gene. G-protein coupled receptor (GPCR) kinase interacting proteins 1 and 2 (GIT-1 and GIT-2) are highly conserved, ubiquitous scaffold proteins involved in localized signaling to help regulate focal contact assembly and cytoskeletal dynamics. GIT proteins contain multiple interaction domains that allow interaction with small GTPases (including ARF, Rac and cdc42), kinases (such as PAK and MEK), the Rho family GEF PIX, and the focal adhesion protein paxillin. GIT-1 is localized to focal adhesions, cytoplasmic complexes and membrane protrusions, and regulates cell protrusion formation and cell migration. GIT-1 has also been implicated in neuronal functions including synapse formation and the pathology of Huntington disease. Huntington disease is a genetic neurodegenerative condition involving a mutation in the huntington gene. The huntington gene product (htt) is ubiquitinated and degraded in human Huntington disease brains. Htt interacts directly with GIT-1 causing enhanced htt proteolysis, indicating that GIT-1 distribution and function may contribute to Huntington disease pathology.
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UniProt
- Q9Y2X7
抗原
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