S100A8 抗体 (AA 400-600)
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Quick Overview for S100A8 抗体 (AA 400-600) (ABIN7874778)
抗原
See all S100A8 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 400-600
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原理
- MRP8 Antibody / Multidrug resistance-associated protein 8 / ABCC11
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant fragment (within amino acids 400-600) of human ABCC11/MRP8 protein was used as the immunogen for the MRP8 antibody.
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亚型
- IgG2b, kappa
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应用备注
- Optimal dilution of the MRP8 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the MRP8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- S100A8 (S100 Calcium Binding Protein A8 (S100A8))
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别名
- MRP8
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背景
- ATP-binding cassette (ABC) transporters belong to an evolutionarily conserved family of proteins that catalyze the transport of molecules across extra- and intracellular membranes through the energy of ATP hydrolysis. ABC genes comprise seven subfamilies, designated ABC1, MDR/TAP, MRP, ALD, OABP, GCN20 and White. The complete human ABCC subfamily has 12 identified members (ABCC1-12), nine from the multidrug resistance-like subgroup, two from the sulfonylurea receptor subgroup, and the CFTR gene. The human ABCC11 gene maps to chromosome 16q12.1 and encodes a 1,382 amino acid protein. The human ABCC12 gene maps to chromosome 16q12.1 and encodes a 1,359 amino acid protein. Transcripts of ABCC11 and ABCC12 genes are present in various adult human tissues, including liver, lung and kidney, and also in several fetal tissues. Their chromosomal localization, potential function and expression patterns identify them as candidates for paroxysmal kinesigenic choreoathetosis, a disorder characterized by attacks of involuntary movements and postures, chorea and dystonia. Other inherited disorders where ABC transporters are implicated include cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia and drug response.
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UniProt
- Q96J66
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途径
- Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, S100 Proteins
抗原
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