TICAM1 抗体 (AA 385-448)
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北京 101111
Quick Overview for TICAM1 抗体 (AA 385-448) (ABIN7874539)
抗原
See all TICAM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 385-448
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原理
- TICAM1 Antibody / TRIF
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids S385-H448) was used as the immunogen for the TICAM1 antibody.
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亚型
- IgG
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anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 443-685) antibody
TICAM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 263-526) antibodyTICAM1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibodyTICAM1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (Internal Region) antibodyTICAM1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (C-Term) antibodyTICAM1 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (C-Term) antibodyTICAM1 适用: 人 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (Internal Region) antibodyVerified TICAM1 适用: 人 IHC, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 120-420) antibodyTICAM1 适用: 人, 猴 WB 宿主: 小鼠 Monoclonal 1G7 unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 115-143), (N-Term) antibodyTICAM1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 53-84), (N-Term) antibodyTICAM1 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TICAM1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TICAM1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
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别名
- TICAM1
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背景
- TICAM1 (TIR DOMAIN-CONTAINING ADAPTOR MOLECULE 1), also known as TRIF, is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. By genomic sequence analysis, Oshiumi et al. (2003) mapped the TICAM1 gene to chromosome 19p13.3. By coimmunoprecipitation analysis, Oshiumi et al. (2003) showed that TICAM1 interacts specifically with TLR3, but not with other TLRs. Functional analysis showed that the association of TLR3 and TICAM1 mediates dsRNA activation of IFNB, through NFKB, AP1, or IRF3. TICAM1 activation of NFKB was found to occur predominantly through IRAK1 rather than IRAK2. Small interfering (si)RNA blockage of TICAM1, just upstream of the TIR domain, reduced IFNB production in response to dsRNA.
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UniProt
- Q8IUC6
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
抗原
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