NRF2 抗体 (AA 34-605)
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Quick Overview for NRF2 抗体 (AA 34-605) (ABIN7874087)
抗原
See all NRF2 (NFE2L2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 34-605
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原理
- NRF-2 Antibody / NFE2L2
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纯化方法
- Affinity purified
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免疫原
- Recombinant human protein (amino acids R34-N605) was used as the immunogen for the NRF-2 antibody.
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亚型
- IgG
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anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (pSer40) antibody
NFE2L2 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 430-480) antibodyNFE2L2 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 366-605) antibodyNFE2L2 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (Internal Region) antibodyNFE2L2 适用: 人, 大鼠 WB, IF, IP, ICC, IHC (p), ChIP 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 382-604) antibodyNFE2L2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (acLys599) antibodyNFE2L2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (acLys599) antibodyNFE2L2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (N-Term) antibodyNFE2L2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 356-589) antibodyNFE2L2 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 1A6G6 unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (pSer40) antibodyNFE2L2 适用: 人, 小鼠, 大鼠 WB, FACS, IHC (p), IF (cc) 宿主: 兔 Monoclonal 7G4 unconjugated
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应用备注
- Optimal dilution of the NRF-2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the NRF-2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))
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别名
- NRF-2
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背景
- NFE2L2 (nuclear factor (erythroid-derived 2)-like 2) also known as NRF2 or NFE2-RELATED TRANSCRIPTION FACTOR 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NFE2, NFE2L1, and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. NFE2L2 induces the expression of various genes including those that encode for several antioxidant enzymes, and it may play a physiological role in the regulation of oxidative stress. The NFE2L2 gene is located on 2q31.2. The identification of somatic mutations that disrupt the NRF2-KEAP1 interaction to stabilize NRF2 and increase the constitutive transcription of NRF2 target genes indicated that enhanced reactive oxygen species (ROS) detoxification and additional NRF2 functions may in fact be tumorigenic. Oncogene-directed increased expression of Nrf2 is a mechanism for the activation of the Nrf2 antioxidant program evident in primary cells and tissues of mice expressing KRas(G12D) and BRaf(V619E), and in human pancreatic cancer.
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UniProt
- Q16236
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途径
- ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
抗原
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