MSH2 抗体 (AA 327-427)
Our Local Distributor
北京 101111
Quick Overview for MSH2 抗体 (AA 327-427) (ABIN7873978)
抗原
See all MSH2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 327-427
-
原理
- MSH2 Antibody
-
纯化方法
- Protein G affinity chromatography
-
免疫原
- A recombinant human partial protein (amino acids 327-427) was used as the immunogen for this MSH2 antibody.
-
亚型
- IgG1, kappa
-
-
-
-
应用备注
- Optimal dilution of the MSH2 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.2 mg/mL
-
缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store the MSH2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
-
-
- MSH2 (Mismatch Repair Protein 2 (MSH2))
-
别名
- MSH2
-
背景
- Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
-
UniProt
- P43246
-
途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
-