FLT1 抗体 (AA 32-1229)
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Quick Overview for FLT1 抗体 (AA 32-1229) (ABIN7873906)
抗原
See all FLT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 32-1229
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原理
- Zebrafish Flt1 Antibody / Vegfr1 / Vegf receptor 1
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Flt1 recombinant protein (amino acids L32-K1229) was used as the immunogen for the Zebrafish Flt1 antibody.
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亚型
- Ig Fraction
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anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 1162-1260) antibody
FLT1 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 20-300) antibodyFLT1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (pTyr1213) antibodyFLT1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 1100-1200) antibodyFLT1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) antibodyFLT1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB16736 unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 1-687) antibodyFLT1 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) antibodyFLT1 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 23GB5440 unconjugated Recombinant Antibody
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) antibodyKD Validated FLT1 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB7115 unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 278-298), (N-Term) antibodyFLT1 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 1-380) antibodyFLT1 适用: 人 WB 宿主: 小鼠 Monoclonal 1453CT519-277-79 unconjugated
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应用备注
- Optimal dilution of the Zebrafish Flt1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Flt1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
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别名
- Flt1
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背景
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Fms-related tyrosine kinase 1 (Flt1), also known as vascular endothelial growth factor receptor 1 (VEGFR-1), is a high-affinity receptor for members of the vascular endothelial growth factor (VEGF) family. In zebrafish (Danio rerio), the flt1 gene encodes a transmembrane receptor tyrosine kinase that plays a critical role in vascular development and angiogenesis.
Zebrafish Flt1 is expressed in endothelial cells and is involved in the regulation of blood vessel formation by modulating VEGF signaling. Unlike its counterpart Kdrl (zebrafish VEGFR-2), which promotes angiogenic signaling, Flt1 primarily functions as a decoy receptor that binds VEGF-A and VEGF-B with high affinity, thereby fine-tuning angiogenic responses during embryogenesis. Zebrafish also express a soluble form of Flt1 (sFlt1), which lacks the intracellular kinase domain and acts as a natural inhibitor of VEGF signaling.
Expression of flt1 in zebrafish is detected early during embryonic development, particularly in developing vasculature such as the dorsal aorta, cardinal vein, and intersegmental vessels. Disruption of flt1 leads to aberrant vessel patterning and excessive endothelial sprouting, highlighting its essential regulatory function in vascular morphogenesis.
Due to the optical transparency of zebrafish embryos and the availability of vascular reporter lines, zebrafish Flt1 serves as a powerful model for studying angiogenesis, vascular remodeling, and the mechanisms of VEGF signaling in vivo. It is also a valuable tool for investigating vascular defects, cancer biology, and responses to anti-angiogenic therapies.
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UniProt
- B3DKP1
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途径
- RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
抗原
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