Recombinant AMACR 抗体 (AA 297-394)
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Quick Overview for Recombinant AMACR 抗体 (AA 297-394) (ABIN7873468)
抗原
See all AMACR 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 297-394
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原理
- Recombinant AMACR/p504S Antibody (azide and preservative free)
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纯化方法
- Protein G affinity chromatography
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免疫原
- A human recombinant partial protein (amino acids 297-394) was used as the immunogen for the recombinant AMACR/p504S antibody.
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亚型
- IgG1, kappa
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anti-alpha-Methylacyl-CoA Racemase (AMACR) (AA 297-394) antibody
AMACR 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal AMACR-1864 unconjugated
anti-alpha-Methylacyl-CoA Racemase (AMACR) antibodyAMACR 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 小鼠 Monoclonal unconjugated
anti-alpha-Methylacyl-CoA Racemase (AMACR) antibodyAMACR 适用: 人, 小鼠, 大鼠, 豚鼠, Hamster WB, IHC 宿主: 小鼠 Monoclonal AMACR-1723 unconjugated
anti-alpha-Methylacyl-CoA Racemase (AMACR) (AA 323-351), (C-Term) antibodyAMACR 适用: 人 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal RB18736 unconjugated
anti-alpha-Methylacyl-CoA Racemase (AMACR) antibodyAMACR 适用: 人, 小鼠 WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 2A10F3 unconjugated
anti-alpha-Methylacyl-CoA Racemase (AMACR) (AA 1-198) antibodyAMACR 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-alpha-Methylacyl-CoA Racemase (AMACR) (AA 323-351) antibodyAMACR 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-alpha-Methylacyl-CoA Racemase (AMACR) (AA 312-326) antibodyVerified AMACR 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-alpha-Methylacyl-CoA Racemase (AMACR) (AA 297-394) antibodyAMACR 适用: 人 WB, IHC 宿主: 兔 Monoclonal AMACR-2748R unconjugated Recombinant Antibody
anti-alpha-Methylacyl-CoA Racemase (AMACR) antibodyAMACR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the recombinant AMACR/p504S antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the recombinant AMACR/p504S antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- AMACR (alpha-Methylacyl-CoA Racemase (AMACR))
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别名
- AMACR/p504S
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背景
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AMACR/p504S antibody is used to study Alpha-methylacyl-CoA racemase, a peroxisomal and mitochondrial enzyme involved in the beta-oxidation of branched-chain fatty acids and bile acid intermediates. Alpha-methylacyl-CoA racemase is encoded by the AMACR gene and catalyzes the interconversion of R- and S-stereoisomers of alpha-methyl-branched acyl-CoA substrates, a necessary step for their subsequent degradation through beta-oxidation pathways. This enzymatic activity links AMACR to lipid metabolism and energy homeostasis in metabolically active tissues.
Alpha-methylacyl-CoA racemase is widely known as p504S, a designation that originated from early gene expression studies identifying strong upregulation of this protein in prostate carcinoma. The p504S antigen became an important marker for distinguishing malignant prostate epithelium from benign glands, leading to extensive use of AMACR/p504S antibody in studies of prostate cancer biology and diagnostic marker evaluation. Use of an AMACR/p504S antibody enables investigation of this cancer-associated expression pattern in tissue and cell-based research models.
At the subcellular level, Alpha-methylacyl-CoA racemase localizes primarily to the cytoplasm, with enrichment in peroxisomes and mitochondria, reflecting its role in fatty acid metabolism. This localization supports metabolic processing of branched-chain lipids derived from dietary sources and bile acid synthesis. Studies using AMACR antibody have helped define its compartmentalized activity and its contribution to lipid catabolism in epithelial and metabolic tissues.
Beyond prostate cancer, altered expression of Alpha-methylacyl-CoA racemase has been reported in additional malignancies, including renal cell carcinoma, hepatocellular carcinoma, and colorectal cancer, suggesting broader relevance in tumor-associated metabolic reprogramming. Elevated AMACR expression is thought to reflect increased reliance on lipid metabolism pathways in proliferating tumor cells. Detection of AMACR using an AMACR/p504S antibody supports research into metabolic adaptation, tumor progression, and lipid utilization in cancer biology.
AMACR/p504S antibody (clone rAMACR/1864) is designed to detect Alpha-methylacyl-CoA racemase in research applications. Analysis of AMACR expression provides insight into fatty acid metabolism, peroxisomal and mitochondrial function, and disease-associated metabolic changes. Alpha-methylacyl-CoA racemase remains a key enzyme for studies examining the intersection of lipid metabolism and cancer-associated metabolic remodeling. -
UniProt
- Q9UHK6
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途径
- Monocarboxylic Acid Catabolic Process
抗原
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