IGKV1-27 抗体 (AA 241-356)
The 小鼠 单克隆 anti-IGKV1-27 antibody (Clone TNFAIP3-2813) (ABIN7872742) specifically detects IGKV1-27 in IHC (p).
The antibody is reactive with 人 samples.
产品编号 ABIN7872742
发货至:
中国
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Contact Info
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Quick Overview for IGKV1-27 抗体 (AA 241-356) (ABIN7872742)
抗原
See all IGKV1-27 抗体
IGKV1-27
(Immunoglobulin kappa Variable 1-27 (IGKV1-27))
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This IGKV1-27 antibody is un-conjugated
应用范围
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
克隆位点
TNFAIP3-2813
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抗原表位
- AA 241-356
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原理
- A20 Antibody / TNFAIP3
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纯化方法
- Protein G affinity chromatography
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免疫原
- A portion of amino acids 241-356 from the human protein was used as the immunogen for the A20 antibody.
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亚型
- IgG2c, kappa
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anti-Immunoglobulin kappa Variable 1-27 (IGKV1-27) (Internal Region) antibody
IGKV1-27 适用: 人, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Immunoglobulin kappa Variable 1-27 (IGKV1-27) (Center) antibodyIGKV1-27 适用: 人, 小鼠, 大鼠 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the A20 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the A20 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- IGKV1-27 (Immunoglobulin kappa Variable 1-27 (IGKV1-27))
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别名
- A20
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背景
- A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. High A20 expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade). These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.
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UniProt
- P21580
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途径
- Activation of Innate immune Response
抗原
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