IGKV1-27 抗体 (AA 241-356)
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北京 101111
Quick Overview for IGKV1-27 抗体 (AA 241-356) (ABIN7863458)
抗原
See all IGKV1-27 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 241-356
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原理
- A20 / TNFAIP3 (Marker of Tamoxifen Resistance) Antibody
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特异性
- A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. HighA20expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade). These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa 241-356) of human TNFAIP3 protein (exact sequence is proprietary)
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亚型
- IgG2c, kappa
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anti-Immunoglobulin kappa Variable 1-27 (IGKV1-27) (Internal Region) antibody
IGKV1-27 适用: 人, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Immunoglobulin kappa Variable 1-27 (IGKV1-27) (Center) antibodyIGKV1-27 适用: 人, 小鼠, 大鼠 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- IGKV1-27 (Immunoglobulin kappa Variable 1-27 (IGKV1-27))
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别名
- A20
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背景
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A20, Putative DNA-binding protein A20, TNF alpha-induced protein 3 (TNFAIP3), Tumor Necrosis Factor alpha-Induced Protein 3(TNFAIP3), Zinc finger protein A20
Hodgkin s Lymphoma or hepatocellular carcinoma (HCC).
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分子量
- ~90kDa
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基因ID
- 7128, 211600
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UniProt
- P21580
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途径
- Activation of Innate immune Response
抗原
-
